Results 71 to 80 of about 174,683 (282)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Sperm storage by males causes changes in sperm phenotype and influences the reproductive fitness of males and their sons [PDF]

, 2017
Recent studies suggest that environmentally induced effects on sperm phenotype can influence offspring phenotype beyond the classic Mendelian inheritance mechanism.
Adriaenssens, Aitken, Almbro, Bonduriansky, Bonduriansky, Boschetto, Crean, Crean, Crean, Curley, El Jack, Evans, Evans, Evans, Evans, Falconer, Firman, Franco, Froman, Gasparini, Gasparini, Gasparini, Gasparini, Head, Holt, Houde, Immler, Immler, Jensen, Jones, Kilgallon, Lynch, Marshall, Orr, Parker, Perry, Pilastro, Pilastro, Pilastro, Pizzari, Poiani, R Development Core Team, Rahman, Rahman, Reinhardt, Reinhardt, Sheldon, Simmons, Simmons, Siva-Jothy, Tan, Tarin, Vasudeva, White, Zajitschek   +54 more
core   +1 more source

Extending an eco-evolutionary understanding of biofilm-formation at the air-liquid interface to community biofilms [PDF]

, 2020
Growing bacterial populations diversify to produce a number of competing lineages. In the Pseudomonas fluorescens SBW25 model system, Wrinkly Spreader mutant lineages, capable of colonising the air-liquid interface of static microcosms by biofilm ...
Jerdan, Robyn, Lungin, Olga, Moshynets, Olena V., Potters, Geert, Spiers, Andrew J.   +4 more
core   +3 more sources

From dry-land to the water: training and testing practices of strength and conditioning coaches in high level French sprint swimmers

Frontiers in Sports and Active Living
IntroductionThe aim of this study was to explore training and testing practices from Strength & Conditioning (S&C) coaches who manage groups of high-level French swimmers in elite training centers.
Yannis Raineteau, Yannis Raineteau, Robin Pla, Benoit Bideau, Benoit Bideau, Nicolas Bideau, Nicolas Bideau, Guillaume Nicolas, Guillaume Nicolas   +8 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

A Qualitative Analysis of Motivation of Elite Female Triathletes [PDF]

, 2010
The multidimensional theoretical framework of Self-Determination Theory (SDT) has gained prominence in the sport and exercise field to assist in understanding human motivation.
Smith, Alexis
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Configural analysis of dry-land strength and front crawl performance in adolescents

Frontiers in Physiology
IntroductionDry-land strength capacities play a crucial role in competitive swimming, especially in short-distance events where explosive force and coordination are decisive.
Tianyi Gao, Jiawen Shen, Baojie Tang, Xinyuan Wu, Yifan Shi, Bo Huang   +5 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Profiling the sport of stand-up paddle boarding [PDF]

, 2015
Stand-up paddle boarding (SUP) is a rapidly growing activity where only anecdotal evidence exists for its proposed health and fitness benefits.
Climstein, Mike, Hing, Wayne, Schram, Ben   +2 more
core   +1 more source