Results 241 to 250 of about 26,393 (301)

Early Detection and Inhibition of Post‐Surgical Cancer Recurrence by Synthetic Extracellular Vesicles

Advanced Science, EarlyView.
An implantable hydrogel is designed to hold gene transfection agents engineered to turn early recurrent tumor cells into generators of synthetic EVs. These synthetic EVs can express engineered miR‐26a (E‐miR‐26a) for highly sensitive detection and PD‐1 (a PD‐L1‐blocking agent) for therapeutic intervention, thereby enabling early detection and ...
Junli Zhang, Wenjia Chang, Ruolin Hu, Peiyan Su, Qin Zhou, Yanan Li, Zhenzhong Zhang, Kaixiang Zhang   +7 more
wiley   +1 more source

Resilience of science after austerity. [PDF]

PNAS Nexus
Sun Y, Ma A, von Graevenitz G, Latora V.
europepmc   +1 more source

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

DTX3L Inhibits the EMT, Metastasis, and Stem‐Like Features of Gastric Cancer Through Promoting GSK‐3β Dependent SNAI1 Decay

Advanced Science, EarlyView.
This research identifies DTX3L as a critical tumor suppressor that inhibits epithelial‐mesenchymal transition (EMT), invasion and metastasis in gastric cancer. By functioning as an E3 ubiquitin ligase, DTX3L targets the master EMT regulator SNAI1 for GSK‐3β‐dependent proteasomal degradation.
Yang Chen, Zhen Li, Jiajia Shen, Jingyu Lin, Xiaoli Zhao, Rui Zhang, Ying Han, Zhen Wang   +7 more
wiley   +1 more source

Social status and the relationship between income rank and well-being in 109 nations. [PDF]

Nat Commun
Quispe-Torreblanca E, De Neve JE, Brown GDA.   +2 more
europepmc   +1 more source

MetalCenter‐Dependent Selectivity Divergence in MN4 Single‐Atom Catalysts for Aerobic HMF Oxidation

Advanced Science, EarlyView.
Two single‐atom catalysts with M‐N4 configurations (FeN4 and CoN4) were developed for selective HMF oxidation. FeN4 achieves 93.9% selectivity toward FFCA via superoxide anions (O2•−), while CoN4 preferentially produces FDCA through hydroxyl radicals (•OH). DFT calculations reveal that distinct adsorption energies and charge redistribution at the metal
Haoyu Wang, Zhilong Ye, Weihao Wang, Zhi Hu, Qing Tian, Jie Gao, Lianbing Zhang   +6 more
wiley   +1 more source

Silicon wafers outperform batteries: efficiency heterogeneity and policy effects in China's photovoltaic industry. [PDF]

Sci Rep
Li WQ, Liu HL, Liu XY, Ren FR.
europepmc   +1 more source

Gene Expression Pattern Associated with Cytoskeletal Remodeling in Lipid-Loaded Human Vascular Smooth Muscle Cells: Crosstalk Between C3 Complement and the Focal Adhesion Protein Paxillin. [PDF]

Cells
Garcia-Arguinzonis M, Escate R, Lugano R, Peña E, Borrell-Pages M, Badimon L, Padro T.   +6 more
europepmc   +1 more source

Regulatory rewiring drives intraspecies competition in Bacillus subtilis. [PDF]

PLoS Genet
Kalamara M, Bonsall A, Griffin J, Carneiro J, Gierlinski M, Eigentler L, Stevenson D, Wood A, Porter M, Dorfmueller HC, MacPhee CE, Abbott JC, Stanley-Wall NR.   +12 more
europepmc   +1 more source

Ecosystem simulation: the software to platform leap. [PDF]

Sci Rep
Liu Z, Cui Y, Zhang Y, Li Z, Liu X, Wang S.   +5 more
europepmc   +1 more source