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Impact of Prior Biologic Mechanism of Action on Anti‐TNF Effectiveness in Inflammatory Bowel Disease: An ENEIDA Registry Study

Alimentary Pharmacology &Therapeutics, EarlyView.
In this nationwide ENEIDA registry study, anti‐TNF therapy after prior exposure to a different biologic mechanism of action showed reduced treatment durability in inflammatory bowel disease, with a particularly marked impact in ulcerative colitis, where short‐ and long‐term clinical effectiveness was also lower. ABSTRACT Background The expanding use of
Carmen Yagüe Caballero +85 more
wiley +1 more source

Intrinsic and Extrinsic Circular Dichroism in Linear Arrays of Anisotropic Chiral Nanoparticles. [PDF]

Nano Lett
Chow TH +7 more
europepmc +1 more source

HLA‐A*11:01 Identifies Patients at Risk for Persistent Viraemia and Advanced Fibrosis in HDV Infection

Alimentary Pharmacology &Therapeutics, EarlyView.
The HLA‐A*11:01 allele is associated with persistent viraemia and advanced liver fibrosis in HDV infection. HLA‐A*11:01 carriers exhibit a reduced T‐cell repertoire, suggesting a narrower T‐cell response to the infection. ABSTRACT Background Hepatitis delta virus (HDV) infection causes the most severe form of viral hepatitis, with highly heterogeneous ...
Maria Francesca Cortese +11 more
wiley +1 more source

Competitividade

, 2022
openaire +1 more source

The Flavonoids Daidzein and Genistein Induce Wall-Deficient Cell Formation in Streptomyces coelicolor Under Hyperosmotic Stress. [PDF]

Microb Biotechnol
Valdés-Chiara P +3 more
europepmc +1 more source

Exploring Use‐Wear Texture Quantification Through Confocal Microscopy on Tools Made From Volcanic Rocks (Basalt and Phonolite)

Archaeometry, EarlyView.
ABSTRACT Functional analysis is essential for reconstructing lithic tool use. Recent approaches combining confocal microscopy and surface texture analysis provide quantitative alternatives to traditional visual use‐wear analysis, although their application to coarse‐grained, heterogeneous rocks remains challenging because of their complex surface ...
Idaira Brito‐Abrante +2 more
wiley +1 more source

Correlating Synthesis, Structure, and Thermal Stability of CuBi Nanowires for Spintronic Applications by Electron Microscopy and <i>in Situ</i> Scattering Methods. [PDF]

ACS Nano
Guedeja-Marrón A +12 more
europepmc +1 more source

Functional assessment of inherited myeloid neoplasm‐associated SAMD9L germline variants via Monoallelic CRISPR modelling

British Journal of Haematology, EarlyView.
Summary While the majority of myeloid neoplasms are sporadic, the increasing application of germline genetic testing has led the World Health Organization to designate ‘Myeloid malignancies with germline predisposition’ as a distinct clinical entity, carrying major implications for clinical care and research.
Elena Vuelta +9 more
wiley +1 more source

Fe Incorporation in Ni-Based Layered Hydroxides: Implications for Oxygen Evolution Electrocatalysis. [PDF]

Inorg Chem
Jaramillo-Hernández C +5 more
europepmc +1 more source

Patient‐derived surgical samples reveal the cellular and molecular signatures of glioblastoma infiltration in distinct radiological zones

Brain Pathology, EarlyView.
Integrated histological and transcriptional profiling of the glioblastoma periphery reveals clinically relevant tumor infiltration beyond MRI‐defined boundaries. MRI‐guided biopsies from contrast‐enhancing (CE), non‐contrast‐enhancing (nCE), edema (E), and radiologically normal (N) regions demonstrate that nCE areas frequently retain neoplastic and ...
Olaya de Dios +18 more
wiley +1 more source

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