Results 201 to 210 of about 236,619 (301)

Parallel Pathways and Alternative Macrocyclizations in the Biosynthesis of Largimycins by Cytochrome P450 Minus Mutants of <i>Streptomyces argillaceus</i>. [PDF]

J Nat Prod
Becerril A, Pérez-Victoria I, Martín J, Salas JA, Reyes F, Méndez C.   +5 more
europepmc   +1 more source

Olfactory proteomics reveals the capacity of the HDAC1 inhibitor pyroxamide to halt the α‐synuclein preformed fibrils‐induced damage in nasal epithelial, microglial and dopaminergic neuronal cell lines

Brain Pathology, EarlyView.
Omics‐driven drug repositioning reveals pyroxamide as a neuroprotective HDAC1 inhibitor in Parkinson's disease models. Abstract Parkinson's disease (PD) is the second most common neurodegenerative disorder mainly characterized by the degeneration of dopaminergic neurons originating in the substantia nigra (SN) pars compacta and projecting to other ...
Paz Cartas‐Cejudo, Marina De Miguel, Leire Extramiana, Mercedes Lachén‐Montes, Silvia Romero‐Murillo, Djordje Gveric, Joaquín Fernández‐Irigoyen, Enrique Santamaría   +7 more
wiley   +1 more source

HUPA: A corpus of disordered and normophonic voices in Castilian Spanish. [PDF]

Data Brief
Puerta-Acevedo JC, Alcalá-Durand MF, Mendes-Laureano J, Arias-Londoño JD, Godino-Llorente JI.   +4 more
europepmc   +1 more source

Decellularised Corneal Stromal Lamina With or Without Autologous Adipose‐Derived Adult Stem Cells for Advanced Keratoconus: 1‐Year Results of a Phase I/IIa Clinical Trial

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background To report the 1‐year clinical outcomes of decellularised human corneal stromal lamina implantation, with or without autologous adipose‐derived adult stem cells (ADASCs), for advanced keratoconus in a European cohort. Methods In this prospective, randomised Phase I/IIa trial, 10 eyes of 10 patients were allocated to decellularised ...
Hao Zhang, Jorge L. Alió del Barrio, Alejandra E. Rodriguez, Rafael I. Barraquer, Francisco Arnalich‐Montiel, David Mingo‐Botín, María Eugenia Fernández Santos, Jorge L. Alió   +7 more
wiley   +1 more source

Rib Cross-Sectional Mineralized Area in Early Pleistocene Hominins: Insights From the Homo antecessor and H. erectus s. l. Fossil Record. [PDF]

Am J Biol Anthropol
López-Rey JM, García-Martínez D, Gómez-Olivencia A, Cambra-Moo O, González-Martín A, Bastir M, Bermúdez de Castro JM.   +6 more
europepmc   +1 more source

Surviving Males With PORCN Variants: Expanding the Clinical, Molecular, and Mechanistic Spectrum

Clinical Genetics, EarlyView.
Pathogenic PORCN variants are compatible with male survival in both mosaic and non‐mosaic states, expanding the FDH/PONGOS spectrum and improving diagnosis and genetic counseling. ABSTRACT Pathogenic variants in PORCN cause focal dermal hypoplasia (FDH/Goltz syndrome), an X‐linked dominant disorder historically considered lethal in males, with milder ...
Lucía Miranda‐Alcaraz, Simone Carbonera, Mónica Mora‐Gómez, Natalia Gallego‐Zazo, Inmaculada Guillén, Elena Padilla, Gaia Visani, Alessia Asaro, Valeria Vásquez‐Amell, Mario Cazalla, Manuel Rodríguez‐Canó, Cristina Silván, Pedro Arias, Juan Andrés Jiménez‐Estrada, Tomás Valle, Alejandro Cruz‐Utrilla, Pilar Escribano‐Subías, Nuria Ochoa Parra, María Jesús del Cerro Marín, Julián Nevado, Spanish PAH Consortium, Pablo Lapunzina, Fabio Sirchia, Jair Tenorio‐Castano   +23 more
wiley   +1 more source

Patient Stratification for Serum LDH Levels Reveals Distinct CLA⁺ T-Cell Cytokine Secretion in Response to HDM, Clinical Features and Allergic Comorbidities. [PDF]

Int J Mol Sci
García-Jiménez I, Figueras-Nart I, Sans-de San Nicolás L, Curto-Barredo L, Bertolín-Colilla M, Bonfill-Ortí M, Díez-Ribas S, Llobet-Del Pino A, Guilabert-Vidal A, Ryzhkova A, Ferran M, Pujol RM, Santamaria-Babí LF.   +12 more
europepmc   +1 more source

TreeON: Reconstructing 3D Tree Point Clouds from Orthophotos and Heightmaps

Computer Graphics Forum, EarlyView.
Abstract We present TreeON, a novel neural‐based framework for reconstructing detailed 3D tree point clouds from sparse top‐down geodata, using only a single orthophoto and its corresponding Digital Surface Model (DSM). Our method introduces a new training supervision strategy that combines both geometric supervision and a differentiable shadow and ...
Angeliki Grammatikaki, Johannes Eschner, Pedro Hermosilla, Oscar Argudo, Manuela Waldner   +4 more
wiley   +1 more source

Purple phototrophic bacteria release crotonate as a metabolic overflow pathway. [PDF]

Commun Biol
Allegue LD, Ventura M, Vlaeminck SE, Melero JA, Leroy B, Puyol D.   +5 more
europepmc   +1 more source

Terrain Synthesis and Authoring based on Iso‐Contours

Computer Graphics Forum, EarlyView.
Abstract Digital terrains are central to realistic landscape depiction, yet authoring tools must balance perceptual realism with intuitive artistic control. We propose a compact vector‐based representation that models terrain as nested iso‐contours, inspired by geomorphology and cartography.
B. Huftier, H. Schott, E. Galin, O. Argudo, A. Peytavie, E. Guérin   +5 more
wiley   +1 more source