Results 51 to 60 of about 97,953 (247)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Pengembangan Bahan Ajar Kompilasi Fisika Matematika II Pokok Bahasan Persamaaan Diferensial Untuk Meningkatkan Penalaran Matematis

JPFT (Jurnal Pendidikan Fisika dan Teknologi), 2017
This study aims to develop and produce teaching materials compilation of mathematical physics II on the subject of differential equations. Teaching materials that have been developed in the form of teaching modules.
I Wayan Gunada, Joni Rokhmat, Hikmawati Hikmawati, Kesipudin Kesipudin   +3 more
doaj   +1 more source

Knowledge compilation

Annals of Mathematics and Artificial Intelligence
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Adnan Darwiche, Pierre Marquis
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Development and reliability and validity test of self-efficacy scale for caregivers of type 2 diabetes

Huli yanjiu, 2020
ObjectiveTo compile the self⁃efficacy scale for caregivers of type 2 diabetes patients and test its reliability and validity,in order to provide a tool for assessing the self⁃efficacy of diabetic caregivers.MethodsA pool of entries was formed on the ...
DAI Qi, DING Yaping, XU Jingjing, YU Jie
doaj  

Compiler Verification and Compiler Architecture

Electronic Notes in Theoretical Computer Science, 2002
AbstractWe study issues in verifying compilers for modern imperative and object-oriented languages. We take the view that it is not the compiler but the code generated by it which must be correct. It is this subtle difference that allows for reusing standard compiler architecture, construction methods and tools also in a verifying compiler.Program ...
openaire   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Techniques in minimally invasive transperitoneal pyeloplasty: A compilation

Urology Annals
Context: Minimally invasive management (laparoscopic/robot assisted) is currently the standard of care for managing pelvi ureteric junction obstruction (PUJO). Open techniques of management of PUJO are well described in literature. However, there appears
Chiruvella Mallikarjuna, Syed Mohammed Ghouse, Vijay Kumar Sarma Madduri, Mohammed Taif Bendigeri, Bhavatej Enganti, Purnachandra Reddy, Gopal Ramdas Tak   +6 more
doaj   +1 more source