Results 191 to 200 of about 559,551 (362)

Development of Carbon‐11 Labeled Pyrimidine Derivatives as Novel Positron Emission Tomography (PET) Agents Enabling Brain Sigma‐1 Receptor Imaging

open access: yesAdvanced Science, EarlyView.
Novel carbon‐11 labeled pyrimidine derivatives are developed as PET imaging probes for visualizing sigma‐1 receptors in the brain. [11C]CNY‐01 demonstrates superior brain uptake and binding specificity in both rodents and non‐human primates. The study reveals decreased sigma‐1 receptor expression in Alzheimer's disease, offering a promising tool for ...
Ping Bai   +12 more
wiley   +1 more source

Translating programming languages for intermediate codes [PDF]

open access: yesInformatică economică, 2007
Many of the important data structures used in a compiler are intermediate representations of the program being compiled. Often these representations take the form of trees, with several node types, each of which has different attributes.
doaj  

Identification of Tumor‐Specific Surface Proteins Enables Quantification of Extracellular Vesicle Subtypes for Early Detection of Pancreatic Ductal Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) extracellular vesicle (EV) surface protein assay operates via a two‐step workflow – Step 1: Click chemistry‐mediated enrichment of PDAC EVs by EV Click Beads, in the presence of one of the three trans‐cyclooctene‐grafted PDAC EV‐specific antibodies; Step 2: Quantification of the enriched PDAC EVs by reverse ...
Chen Zhao   +27 more
wiley   +1 more source

Recent Advances in mRNA Delivery Systems for Cancer Therapy

open access: yesAdvanced Science, EarlyView.
This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang   +9 more
wiley   +1 more source

A full-stack memristor-based computation-in-memory system with software-hardware co-development. [PDF]

open access: yesNat Commun
Yu R   +14 more
europepmc   +1 more source

Disturbance‐Aware On‐Chip Training with Mitigation Schemes for Massively Parallel Computing in Analog Deep Learning Accelerator

open access: yesAdvanced Science, EarlyView.
This study proposes novel operational schemes to solve the write disturbance issues in oxide‐semiconductor and capacitor‐based synaptic devices (6T1C devices). These schemes effectively neutralize disturbances, enabling high‐performance on‐chip training of convolutional neural networks and reducing capacitor size over 100 times.
Jaehyeon Kang   +6 more
wiley   +1 more source

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