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Complement C3a and C4a Increased in Plasma of Patients with Aspirin-induced Asthma [PDF]
American Journal of Respiratory and Critical Care Medicine, 2006 Aspirin-induced asthma (AIA) is a distinct clinical syndrome that affects up to 10% of adults with asthma. Although eicosanoid metabolites appear to play an important role in AIA, the exact pathogenic mechanism for the syndrome remains obscure. In addition, the proposed mechanism fails to explain why aspirin does not cause bronchoconstriction in all ...
Seung Ha Lee +7 more
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Complexes of IgG molecules and C3a and C4a complement components in human serum [PDF]
European Journal of Immunology, 1992 AbstractA heterogeneous group of proteins was separated from human serum IgG using 5 M guanidine hydrochloride solution in 0.1 M acetic acid. The protein mixture was fractionated by reverse‐phase high‐performance liquid chromatography and two proteins were isolated and identified as the C3a and C4a complement components (anaphylatoxins) according to ...
Roald Nezlin, Andrew Freywald
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Glomerular deposition of the complement C4 isotypes C4A and C4B in glomerulonephritis
Nephrology Dialysis Transplantation, 1996Complement C4 is a component of the classical complement pathway, which is a major mediator of inflammation in many forms of glomerulonephritis. The two isoforms of C4-C4A and C4B-differ in their physicochemical and functional properties.The glomerular deposition of C4A and C4B was investigated in 39 cases of glomerulonephritis with classical pathway ...
Karl Lhotta +4 more
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The phenotype of SLE associated with complete deficiency of complement isotype C4A.
Journal of clinical immunology, 1998Complete deficiency of the complement C4A isotype is a known genetic risk factor for systemic lupus erythematosus (SLE). The disease phenotype of C4A-deficient patients has never been defined. Among 200 patients with SLE from five centers, 18 (9%) with C4A deficiency were identified.
Thomas R. Welch +6 more
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Complement Components C4A and C4B in Human Lupus
2005For over half a century low serum complement C4 concentrations have been recognized as a manifestation of systemic lupus erythematosus (SLE). However, the role of C4 in human SLE remains elusive. This is partly because of the unusually complex C4 genetics with frequent variations in gene number, gene size, protein isoforms, and expression levels.
Robert M. Rennebohm +9 more
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Human Molecular Genetics, 1994
Twelve transcriptional units have now been located in a 160 kb segment of DNA that includes the genes encoding members of the serum complement system C2, Factor B (Bf) and C4 within the class III region of the human major histocompatibility complex (MHC).
C. Sargent +5 more
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Twelve transcriptional units have now been located in a 160 kb segment of DNA that includes the genes encoding members of the serum complement system C2, Factor B (Bf) and C4 within the class III region of the human major histocompatibility complex (MHC).
C. Sargent +5 more
semanticscholar +1 more source
Complement Activation Products C3a and C4a as Endogenous Antimicrobial Peptides
International Journal of Peptide Research and Therapeutics, 2009All vertebrate species are constantly challenged by infectious agents and pathogens. In order to fight these infectious agents the human host has developed a sophisticated and powerful immune defense. The complement system, which represents the first defense line of innate immunity is activated immediately, within seconds.
Michael Reuter +2 more
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Complement Factors C3a, C4a, and C5a in Chronic Obstructive Pulmonary Disease and Asthma
American Journal of Respiratory Cell and Molecular Biology, 2004Studies of animal models have shown that the activation of the complement system could have a role in chronic obstructive pulmonary disease (COPD) and asthma by promoting inflammation and enhancing airway hyperresponsiveness. We sought to determine whether the levels of complement factors C3a, C4a, and C5a are elevated at the site of inflammation in ...
Jurij Sorli +6 more
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A comparison of the properties of two classes, C4A and C4B, of the human complement component C4.
The EMBO Journal, 1984A remarkable difference has been observed between the reactivity of the two forms of human complement component C4. C4B binds twice as effectively as C4A to antibody-coated red cells, but the reverse occurs with protein-antigen complexes. C4B reacts much more effectively with hydroxyl groups than C4A and this is reversed for reaction with amino groups ...
A W Dodds, S K Law, R R Porter
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Molecular BioSystems, 2011
Preeclampsia is a common pregnancy complication that is associated with maternal perinatal morbidity and mortality. Because of its early onset (before 34 weeks) and the potential for serious outcomes, severe, early-onset preeclampsia (sePE) should be regarded as a different form of preeclampsia.
Zengnian Xu +7 more
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Preeclampsia is a common pregnancy complication that is associated with maternal perinatal morbidity and mortality. Because of its early onset (before 34 weeks) and the potential for serious outcomes, severe, early-onset preeclampsia (sePE) should be regarded as a different form of preeclampsia.
Zengnian Xu +7 more
openaire +3 more sources