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Activated complement components C3a and C4a in cerebrospinal fluid and plasma following subarachnoid hemorrhage [PDF]

Journal of Neurosurgery, 1989
✓ The cerebrospinal fluid (CSF) and plasma levels of the complement components C3a and C4a in 40 patients suffering from subarachnoid hemorrhage (SAH) were quantitated by radioimmunoassay. Serial measurements of the lumbar CSF levels revealed that the C3a and C4a levels were significantly elevated in the initial stage of SAH, but decreased rapidly ...
Hidetoshi Kasuya, Takashi Shimizu
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Human Complement Components C4A and C4B Genetic Diversities: Complex Genotypes and Phenotypes

Current Protocols in Immunology, 2005
AbstractThis unit describes methods that can accurately determine the genotypes and phenotypes of human complement components C4A and C4B. Specifically, they allow investigators to determine how many C4 genes are present in a diploid genome of a human subject and to quantify how many of them encode C4A proteins and how many of them encode C4B proteins.
C. Yung Yu, Yan Yang, Erwin K. Chung, Bi Zhou, Yee Ling Wu   +4 more
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Comparative Structural Anatomy of the Complement Anaphylatoxin Proteins C3a, C4a and C5a

Enzyme, 1986
The anaphylatoxins are a family of proteins produced during the course of complement activation as the result of cleavage by specific serine proteases. These proteins are involved in a variety of biological functions, including inflammation. Comparative modeling techniques have been used to produce structures for C4a and C5a from the crystal structure ...
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Allelic distribution of complement components BF, C4A, C4B, and C3 in Psoriasis vulgaris

Immunology Letters, 2002
Psoriasis vulgaris is a multifactorial disease; the strongest association was established with the HLA complex. The actual disease-predisposing gene(s) has not been identified yet, but several genes from this region were examined in addition to HLA-C and -B.
Piotr Nockowski, Jolanta Halasa, Magdalena Prussak, Maria Cisło, Piotr Kuśnierczyk, Feliks Wasik, Mańczak M   +6 more
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DR3 and nonDR3 associated complement component C4A deficiency in systemic lupus erythematosus

Clinical Immunology and Immunopathology, 1991
The molecular basis of complement component C4A deficiency in white U.S. and Mexican patients with systemic lupus erythematosus (SLE) was studied. Genomic DNA from SLE patients and non-SLE controls was analyzed for restriction fragments using HindIII and a 5' C4 cDNA probe.
Priti Kumar, Peter H. Schur, Ashok A. Kumar   +2 more
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Rapid quantification of human complement component C4A and C4B genes by capillary gel electrophoresis

ELECTROPHORESIS, 2006
AbstractComplement component 4 (C4) is an important plasma protein playing a major role in the human defense mechanism against infectious diseases and inflammatory processes. The C4A and C4B genes, encoding the two isoforms of complement 4, are located in the nuclear serine/threonine protein kinase‐C4A or B gene‐cytochrome 21‐hydroxylase‐tenascin X ...
Zsolt Ronai, György Füst, Maria Sasvari-Szekely, Bernadett Blaskó, András Guttman, Ágnes Szilágyi   +5 more
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Low copy-number of complement C4A, the presence of HLA-DR3, and the presence of HLA-DR2 are independent and additive risk factors for human systemic lupus erythematosus (SLE) (93.13)

Journal of Immunology, 2010
The major histocompatibility complex (MHC) in chromosome 6p21.3 has the strongest genetic association with human SLE. This study aims to dissect the roles of MHC genes HLA-DRB1 and complement C4 in SLE.
Yee-Ling Wu, E. Lundström, Chau‐Ching Liu, Yan Yang, I. Gunnarsson, E. Svenungsson, Bi Zhou, K. Jones, H. Nagaraja, G. Higgins, C. Spencer, H. Brunner, D. Birmingham, B. Rovin, B. Tsao, J. Ahearn, L. Hebert, L. Padyukov, Chia-Nien Yu   +18 more
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Purification and functional assessment of C3a, C4a and C5a of the common carp (Cyprinus carpio) complement*1

Developmental & Comparative Immunology, 2004
Promotion of inflammatory response is an important role of the complement system, but this kind of function is poorly documented for the lower vertebrates. Here we report chemotactic activity of purified anaphylactic fragments derived from the complement components C3, C4 and C5 of the common carp.
Miki Nakao, Tomoki Yano, Yoko Kato, Hiroyuki Wariishi, Motoyuki Shimizu   +4 more
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Association of C3 and C4 A Complement Types with Familial Amyloidotic Polyneuropathy

Human Heredity, 1990
A mutant variant of the serum protein transthyretin (TTR-met30) appears to be a necessary but not sufficient condition for the development of familial amyloidotic polyneuropathy (FAP). We have studied a number of serum protein markers (alpha 1-antitrypsin, properdin factor B, C3, C4A, C4B, haptoglobin, transferrin and group-specific component) in FAP ...
Lars Beckman, P.-O. Nylander, Gösta Holmgren, Lars Steen   +3 more
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A novel interaction between complement product C4a and the receptor for advanced glycation end products (RAGE)

Journal of Immunology
Complement proteins (C) including their split products play important roles in host defense and homeostasis. Anaphylatoxins C3a and C5a, by binding to their receptors on immune and non-immune cells, mediate cell recruitment and the release of ...
Fang Wang, Yee Wu
semanticscholar   +1 more source