Results 91 to 100 of about 285,870 (377)

Shared structuring resources across domains : double task effects from linguistic processing on the structural integration of pitch sequences [PDF]

, 2017
Many studies have reported evidence suggesting that resources involved in linguistic structural processing might be domain-general by demonstrating interference from simultaneously presented non-linguistic stimuli on the processing of sentences (Slevc ...
Hartsuiker, Robert, Severens, Els, Van de Cavey, Joris   +2 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A Pipeline for Volume Electron Microscopy of the Caenorhabditis elegans Nervous System. [PDF]

, 2018
The "connectome," a comprehensive wiring diagram of synaptic connectivity, is achieved through volume electron microscopy (vEM) analysis of an entire nervous system and all associated non-neuronal tissues. White et al.
Chisholm, Andrew D, Holmyard, Douglas, Meirovitch, Yaron, Mitchell, James, Mulcahy, Ben, Samuel, Aravinthan DT, Witvliet, Daniel, Zhen, Mei   +7 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Disease detection of brucellosis in goat population in Negeri Sembilan, Malaysia [PDF]

, 2012
A serological study of brucellosis in goats caused by Brucella melitensis was conducted in the state of Negeri Sembilan, Malaysia. A total of 771 serum samples were collected from seven districts namely Rembau, Jelebu, Kuala Pilah, Seremban, Port Dickson,
Bejo, Siti Khairani, Haron, Abd Wahid, Mohd Yusof, Siti Sumaiyah   +2 more
core  

Telomere lengths in human oocytes, cleavage stage embryos and blastocysts [PDF]

, 2010
Telomeres are repeated sequences that protect the ends of chromosomes and harbour DNA-repair proteins. Telomeres shorten during each cell division in the absence of telomerase.
Achi, Aitken, Allsopp, Bailey, Baird, Betts, Blackburn, Cerone, de La Roche Saint-Andre, Dozortsev, Edwards, Evenson, Fiorenza, Fulka, G. M. Hartshorne, Gonzalo, H. P. Wong, Holt, Huang, J. Rai, Keefe, Keefe, Kimura, Lassalle, Liu, Liu, Liu, Longo, McIlrath, Meerdo, Morelli, Murnane, Rodr  guez, S. Turner, Schaetzlein, Tesarik, Valdes, Whitmire, Wong, Wright, Xu, Zhivkova, Zijlmans   +42 more
core   +2 more sources

A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications

Molecular Oncology, EarlyView.
Hypoxia reshapes tumour redox landscapes by altering compartmental ROS production (mitochondria, NOX, ER, peroxisomes). Accurate interpretation requires oxygen‐contextualised measurement (live biosensors, chemical probes, EPR, LC–MS) and awareness of artefacts (reoxygenation, probe specificity).
Lina Hacker, Elysia Sarsam, Stuart J. Conway, Ester M. Hammond   +3 more
wiley   +1 more source

Oropouche Virus Isolation, Southeast Brazil

Emerging Infectious Diseases, 2005
An Oropouche virus strain was isolated from a novel host (Callithrix sp.) in Arinos, Minas Gerais State, southeastern Brazil. The virus was identified by complement fixation test and confirmed by reverse transcription–polymerase chain reaction ...
Márcio Roberto Teixeira Nunes, Lívia Carício Martins, Sueli Guerreiro Rodrigues, Jannifer Oliveira Chiang, Raimunda do Socorro da Silva Azevedo, Amelia P.A. Travassos da Rosa, Pedro Fernando da Costa Vasconcelos   +6 more
doaj   +1 more source

Quantifying tumour-infiltrating lymphocyte subsets : a practical immuno-histochemical method [PDF]

, 2007
Background: Efficient histological quantification of tumour-infiltrating T and B lymphocyte (TIL) subsets in archival tissues would greatly facilitate investigations of the role of TIL in human cancer biology. We sought to develop such a method. Methods:
Alison J. Gray, Bland, Brey, David I. Stott, Guillery, Hussein, Hussein, James J. Going, Liyanage, Matkowskyj, Mufson, Paula M. Loughlin, Poynton, Royet, Ruifrok, Sangwine, Timothy G. Cooke, von Bartheld, W. David George, Willimsky   +19 more
core   +1 more source

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source