Results 31 to 40 of about 42 (40)

Proteomics—The State of the Field: The Definition and Analysis of Proteomes Should Be Based in Reality, Not Convenience

open access: yesProteomes
With growing recognition and acknowledgement of the genuine complexity of proteomes, we are finally entering the post-proteogenomic era. Routine assessment of proteomes as inferred correlates of gene sequences (i.e., canonical ‘proteins’) cannot provide ...
Jens R. Coorssen, Matthew P. Padula
doaj   +1 more source

Unraveling the chicken T cell repertoire with enhanced genome annotation

open access: yesFrontiers in Immunology
T cell receptor (TCR) repertoire sequencing has emerged as a powerful tool for understanding the diversity and functionality of T cells within the host immune system.
Simon P. Früh   +4 more
doaj   +1 more source

Closing the evidence loop—membrane-lipid homeostasis and vesicular transport link DEHP exposure to endometriosis

open access: yesHuman Genomics
Background The causal bridge from environmental exposure to endometriosis (Ems) biology remains incompletely defined. Di(2-ethylhexyl) phthalate (DEHP) is repeatedly implicated in elevated Ems risk, yet actionable molecular anchors linking exposure to ...
Yonggang Dai   +5 more
doaj   +1 more source

Directed evolution–driven reprogramming of PD-L1 for compact and tunable checkpoint modulation

open access: yesJournal of Biological Engineering
Background Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis have achieved major clinical success in cancer therapy. However, IgG-based checkpoint inhibitors face limitations such as large molecular size restricting tumor penetration and ...
Ji Yeon Ha   +6 more
doaj   +1 more source

Investigate the differences in executive functions and behavioral baseline indicators of Parkinson’s disease model mice based on the five - choice serial reaction time task

open access: yesLaboratory Animal Research
Background In the field of neuroscience research, executive functions (EFs) are of great significance. Patients with Parkinson’s disease (PD) often encounter the problem of EFs impairment, which severely affects their lives and health. However, currently,
Heng Gu   +7 more
doaj   +1 more source

Complementarity in Molecular Biology

open access: yesAnnals of the Japan Association for Philosophy of Science, 1992
openaire   +2 more sources
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Complementarity of real-time neutron and synchrotron radiation structural investigations in molecular biology

Crystallography Reports, 2010
General problems of the complementarity of different physical methods and specific features of the interaction between neutron and matter and neutron diffraction with respect to the time of flight are discussed. The results of studying the kinetics of structural changes in lipid membranes under hydration and self-assembly of the lipid bilayer in the ...
V. L. Aksenov, M. A. Kiselev
openaire   +1 more source

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