Results 11 to 20 of about 42 (40)

Novel approaches in cancer treatment: preclinical and clinical development of small non-coding RNA therapeutics

Journal of Experimental & Clinical Cancer Research, 2021
Short or small interfering RNAs (siRNAs) and microRNA (miRNAs) are molecules similar in size and function able to inhibit gene expression based on their complementarity with mRNA sequences, inducing the degradation of the transcript or the inhibition of ...
Rossana Cuciniello, Stefania Filosa, Stefania Crispi   +2 more
doaj   +1 more source

Hybrid Fluorescence and Frequency-Domain Photoacoustic Microscopy for Imaging Development of Parhyale hawaiensis Embryos

Photonics, 2023
Parhyale hawaiensis is a marine crustacean which has emerged as a powerful model organism to study molecular and cellular mechanisms linked to embryonic development and regenerative processes.
George J. Tserevelakis, Emmanouela Tekonaki, Maria Kalogeridi, Ioannis Liaskas, Anastasios Pavlopoulos, Giannis Zacharakis   +5 more
doaj   +1 more source

Complementarity in biology [PDF]

EMBO reports, 2010
Fulvio Mazzocchi asserts that neither systems nor reductionist approaches to the analysis of life are sufficient to understand the complexity of living things. Instead, biology should adopt a mindset in which different explanations for biological phenomena complement each other in a manner similar to the theoretical framework of quantum physics.
openaire   +3 more sources

Carbohydrate Mimetic Peptides for Pan Anti-Tumor Responses

Frontiers in Immunology, 2014
Molecular mimicry is fundamental to biology which transcends to many disciplines ranging from immune pathology to drug design. Structural characterization of molecular partners has provided insight into the origins and relative importance of ...
Thomas eKieber-Emmons, Anastas ePashov, Somdutta eSaha, Behjatolah eMonzavi-Karbassi, Ramachandran eMurali   +4 more
doaj   +1 more source

Conformational Dynamics and Cleavage Sites of Cas12a Are Modulated by Complementarity between crRNA and DNA

iScience, 2019
Summary: Cas12a is an RNA-guided endonuclease, which displays great potentials and several advantages over the well-known Cas9 in genome editing and engineering.
Lujia Zhang, Ruirui Sun, Mengyi Yang, Sijia Peng, Yongxin Cheng, Chunlai Chen   +5 more
doaj   +1 more source

Structural plasticity in the loop region of engineered lipocalins with novel ligand specificities, so-called Anticalins

Journal of Structural Biology: X, 2022
Anticalins are generated via combinatorial protein design on the basis of the lipocalin protein scaffold and constitute a novel class of small and robust engineered binding proteins that offer prospects for applications in medical therapy as well as in ...
S. Achatz, A. Jarasch, A. Skerra
doaj   +1 more source

Development of anti-aflatoxin B1 nanobodies from a novel mutagenesis-derived synthetic library for traditional Chinese medicine and foods safety testing

Journal of Biological Engineering, 2023
Background The main commercially available methods for detecting small molecules of mycotoxins in traditional Chinese medicine (TCM) and functional foods are enzyme-linked immunosorbent assay and mass spectrometry. Regarding the development of diagnostic
Yu-Ching Lee, Gar-Hwa Lai, Tsai-Yu Lin, Tien-Sheng Tseng, Tsung-Hsun Tsai, Wang-Chuan Chen, Cheng-Chung Lee, Keng-Chang Tsai   +7 more
doaj   +1 more source

New computational protein design methods for de novo small molecule binding sites.

PLoS Computational Biology, 2020
Protein binding to small molecules is fundamental to many biological processes, yet it remains challenging to predictively design this functionality de novo.
James E Lucas, Tanja Kortemme
doaj   +1 more source

rDock: a fast, versatile and open source program for docking ligands to proteins and nucleic acids.

PLoS Computational Biology, 2014
Identification of chemical compounds with specific biological activities is an important step in both chemical biology and drug discovery. When the structure of the intended target is available, one approach is to use molecular docking programs to assess
Sergio Ruiz-Carmona, Daniel Alvarez-Garcia, Nicolas Foloppe, A Beatriz Garmendia-Doval, Szilveszter Juhos, Peter Schmidtke, Xavier Barril, Roderick E Hubbard, S David Morley   +8 more
doaj   +1 more source

The past, present and future of immune repertoire biology – the rise of next-generation repertoire analysis

Frontiers in Immunology, 2013
T and B cell repertoires are collections of lymphocytes, each characterised by its antigen-specific receptor. We review here classical technologies and analysis strategies developed to assess Immunoglobulin (IG) and T cell receptor (TR) repertoire ...
Adrien eSix, Adrien eSix, Adrien eSix, Adrien eSix, Adrien eSix, Encarnita eMariotti-Ferrandiz, Encarnita eMariotti-Ferrandiz, Encarnita eMariotti-Ferrandiz, Encarnita eMariotti-Ferrandiz, Wahiba eChaara, Wahiba eChaara, Wahiba eChaara, Wahiba eChaara, Wahiba eChaara, Susana eMagadan, Hang-Phuong ePham, Hang-Phuong ePham, Marie-Paule eLefranc, Thierry eMora, Véronique eThomas-Vaslin, Véronique eThomas-Vaslin, Véronique eThomas-Vaslin, Véronique eThomas-Vaslin, Aleksandra M. Walczak, Pierre eBoudinot   +24 more
doaj   +1 more source