Results 81 to 90 of about 221,310 (292)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Complementarity of renewable energy sources in Brazil using qualitative comparative analysis of causal configurations for SDG 7.2 achievement

Discover Sustainability
Traditional approaches to evaluate progress toward Sustainable Development Goal 7.2 rely on single metrics that fail to capture the complexity of energy transitions in high-renewable systems like Brazil.
Hugo Pimentel Tavares, Eliane Da Silva Christo, Nilo Antônio de Souza Sampaio, João Ercio Miranda Junior, Luiz Guilherme de Andrade Aguiar, Ronald Palandi Cardoso, Maria da Glória Diniz de Almeida   +6 more
doaj   +1 more source

Numerical Approximation of the In Situ Combustion Model Using the Nonlinear Mixed Complementarity Method

Fluids
In this work, we study a numerical method to approximate the exact solution of a simple in situ combustion model. To achieve this, we use the mixed nonlinear complementarity method (MNCP), a variation of the Newton method for solving nonlinear systems ...
Julio César Agustin Sangay, Alexis Rodriguez Carranza, Juan Carlos Ponte Bejarano, José Luis Ponte Bejarano, Eddy Cristiam Miranda Ramos, Obidio Rubio, Franco Rubio-López   +6 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Comparing and seeking complementarity between four farm design approaches

Global Ecology and Conservation, 2019
Motivation: Increasing functional biodiversity in agricultural systems and landscapes is a positive environmental outcome. Farm and landscape design offers an opportunity for improved consistency.
Melissa Anne Beryl Vogt
doaj   +1 more source

Mass customisation systems: complementarities and performance consequences

International Journal of Logistics Research and Applications, 2015
Mass customisation (MC) is considered to be an important competitive tool to increase the performance of manufacturers. Due to the importance of MC as part of the manufacturing process, there is an increasing amount of research devoted to exploring the nature of MC and how to effectively implement MC processes.
Zhang, Min, Qi, Yinan, Zhao, Xiande, Duray, Rebecca   +3 more
openaire   +4 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Visible and near‐infrared image fusion based on information complementarity

CAAI Transactions on Intelligence Technology
Images with complementary spectral information can be recorded using image sensors that can identify visible and near‐infrared spectrum. The fusion of visible and near‐infrared (NIR) aims to enhance the quality of images acquired by video monitoring ...
Zhuo Li, Shiliang Pu, Mengqi Ji, Feng Zeng, Bo Li   +4 more
doaj   +1 more source