Results 91 to 100 of about 1,324,556 (299)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Cost Effective Applications of Complementary and Alternative Medicine

, 2011
Australian consumers have embraced the use of complementary and alternative medicine (CAM). Two in three Australians have used complementary medicines over the past 12 months and approximately 42% of these use CAMs to prevent or manage chronic, high ...
Bensoussan, Alan (R7273)
core  

Defining research priorities in complementary medicine in oncology

, 2012
Objectives: The high usage of complementary and alternative medicines (CAM) by cancer patients is increasing, despite limited research available to support their use.
Bensoussan, Alan (R7273), Robotin, Monica C., Holliday, Cath   +2 more
core   +1 more source

ARO-GNN: Adaptive relation-optimized graph neural networks

Journal of King Saud University: Computer and Information Sciences
Existing Graph Neural Networks (GNNs) suffer from topological noise and attribute distortion when handling complex topology-attribute interactions. To overcome these limitations, we propose Adaptive Relation-Optimized Graph Neural Networks (ARO-GNN). ARO-
Yong Lu, Zhengguo Lin
doaj   +1 more source

ACGRHA-Net: Accelerated multi-contrast MR imaging with adjacency complementary graph assisted residual hybrid attention network

NeuroImage
Multi-contrast magnetic resonance (MR) imaging is an advanced technology used in medical diagnosis, but the long acquisition process can lead to patient discomfort and limit its broader application.
Haotian Zhang, Qiaoyu Ma, Yiran Qiu, Zongying Lai   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Research Priorities for Complementary Medicine in Australia

, 2013
This report identifies research priorities in complementary medicine (CM) that will lead to more targeted research and, as a result, better health outcomes for all Australians. Of critical importance, it reflects the professional opinions of experts from
Bensoussan, Alan (R7273)
core  

The H-Line Signed Graph of a Signed Graph [PDF]

, 2010
For standard terminology and notion in graph theory we refer the reader to Harary; the non-standard will be given in this paper as and when required.
Reddy, Siva Kota, Subramanya, M.S., Rangarajan, R.   +2 more
core   +1 more source

Interpretable graph-based models on multimodal biomedical data integration: a technical review and benchmarking

Nature Communications
Integrating diverse biomedical modalities is essential for robust healthcare insights, and graph-based models are increasingly used to capture complex relational structures. Yet, their clinical translation hinges on interpretability.
Alireza Sadeghi, Farshid Hajati, Ahmadreza Argha, Nigel H. Lovell, Min Yang, Hamid Alinejad-Rokny   +5 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source