Results 91 to 100 of about 334,030 (336)

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B‐cell malignancies

FEBS Letters, EarlyView.
Daniel Bachurski, Michael Hallek
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

The Alternative Appeal [PDF]

, 2011
For decades, Americans expressed dissatisfaction with conventional cancer treatments. I examine the appeal of biological alternatives to surgery, chemotherapy, and radiation therapy for patients with cancer.
DeRoo, Courtney
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Systematic reviews of complementary therapies - an annotated bibliography. Part 1: Acupuncture [PDF]

, 2001
Background Complementary therapies are widespread but controversial. We aim to provide a comprehensive collection and a summary of systematic reviews of clinical trials in three major complementary therapies (acupuncture, herbal medicine, homeopathy ...
A Lee, A Vickers, A Vickers, AH MacLennan, AJ Vickers, AJ Vickers, Andrew Vickers, AR White, AR White, AR White, AR White, B O'Brien, BM Berman, Brian Berman, C Vincent, C Zollman, CJ Vickers, D Jewell, D McCrory, D Melchart, Dieter Melchart, DJ Cook, DL Diehl, DM Eisenberg, E Ernst, E Ernst, E Ernst, E Ernst, E Ernst, E Ernst, E Ernst, E Ernst, G ter Riet, G ter Riet, G ter Riet, G ter Riet, G ter Riet, G ter Riet, G ter Riet, G ter Riet, G ter Riet, G ter Riet, Gerben ter Riet, H Vernon, J Ezzo, J Filshie, J Glanville, J Kleijnen, J Lautenschläger, J Park, Johannes Thormählen, JWG Jacobs, K Linde, K Linde, KJ Thomas, KL Resch, Klaus Linde, LA Smith, M Law, Maria Hondras, MS Araujo, MS Patel, MWvan Tulder, MWvan Tulder, NIH Consensus Development Panel on Acupuncture, P Aikins Murphy, P Harris, P Rosted, PE Harris, R Beck, R Hammerschlag, RA Dobie, RE Goslin, V Brewington, W Longworth   +74 more
core   +4 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Alternative medicinal interventions for oral diseases: Scoping review

Journal of Indian Association of Public Health Dentistry, 2018
Oral diseases hamper the overall systems of our body. People of all age groups and races of different geographic locations are affected by oral diseases which range from dental caries to oral cancer. Therefore, timely dental treatment is needed.
Ananthalekshmy Rajeev, Basavaraj Patthi, Ashish Singla, Ritu Gupta, Ravneet Malhi, Monika Rai   +5 more
doaj   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

The use of homeopathic nosodes in the prevention of mastitis in organic dairy herds (OF0186) [PDF]

, 2005
Mastitis is the most significant disease affecting the health, welfare and economic productivity of dairy cattle and is recognised by Defra as a major economic and welfare concern.
Anon
core