Results 111 to 120 of about 365,866 (275)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The local evaluation of Knutsford’s Healthy Living Network: January 2006 – December 2006
, 2007 This was an exploratory study designed to evaluate the Knutsford Healthy Living Network (KHLN), one of many Healthy Living Centres (HLC) in the UK. The HLC initiative aims to ensure people can achieve their optimum state of health and well-being.
Alford, Simon, Perry, Catherine
core
Evolution and Complementarity? Traditional and Complementary Medicine as Part of the International Human Rights Law Right to Health [PDF]
, 2020 In International Human Rights Law, the International Covenant on Economic, Social and Cultural Rights defines the right to health as the right of everyone to the enjoyment of the highest attainable standard of physical and mental health.
Carne, Greg, Doolan, Angela
core
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
, 2011 For decades, Americans expressed dissatisfaction with conventional cancer treatments. I examine the appeal of biological alternatives to surgery, chemotherapy, and radiation therapy for patients with cancer.
DeRoo, Courtney
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
“Complement-ary” Therapies for Age-Related Macular Degeneration
Ophthalmology Science, 2022 Jonathan B. Lin, MD, PhD +1 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Use of complementary therapies by registered psychologists:An international study [PDF]
, 2015 Boucher, Emma +6 more
core +1 more source