Results 91 to 100 of about 168,680 (293)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
, 2003 Pyrococcus furiosus is an obligatory anaerobic hyperthermophilic archaeon (optimal growth temperature is 100°C ) which can be isolated from deep and shallow marine hydrothermal vent systems.
Ji, Mikyoung Lee
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Infinitival and Gerund-Participial Catenative Complement Constructions in English World-Wide
LanguagesPrevious research on non-finite catenative complementation (for example, start Ving/to V; force NP into Ving/to V) has largely been restricted to BrE and/or AmE.
Peter Craig Collins
doaj +1 more source
Blood, 2016 In this issue of Blood , [Jodele et al][1][1][2] build upon earlier work on the role of complement in the pathophysiology[2][3] and therapy[3][4] of transplant-associated thrombotic microangiopathy (TA-TMA) by exploring genetic predisposition for developing this complication.
openaire +2 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Yeast mutant complementation assays.
, 2016 A. Complementation assay of the yeast tps1Δ tps2Δ mutant. B. Complementation assay of the single tps1Δ mutant. W303-1A is the wild-type control which can grow on bot galactose and glucose. The mutation results in impaired growth on glucose.
Erika Varkonyi-Gasic (66045) +2 more
core +1 more source
Journal of Language ModellingThis paper proposes a formal analysis of two displacement phenomena in Mandarin Chinese, namely inner topicalisation and focus fronting, capturing their correlational relationships with control and complementation.
Chit-Fung Lam
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source