Results 81 to 90 of about 177,591 (297)
Evolution-guided yeast complementation reveals functional differences in human PSPH variants. [PDF]
FEBS Open BioAncient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Campa-Álvarez M +6 more
europepmc +2 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Infinitival and Gerund-Participial Catenative Complement Constructions in English World-Wide
LanguagesPrevious research on non-finite catenative complementation (for example, start Ving/to V; force NP into Ving/to V) has largely been restricted to BrE and/or AmE.
Peter Craig Collins
doaj +1 more source
Blood, 2016 In this issue of Blood , [Jodele et al][1][1][2] build upon earlier work on the role of complement in the pathophysiology[2][3] and therapy[3][4] of transplant-associated thrombotic microangiopathy (TA-TMA) by exploring genetic predisposition for developing this complication.
openaire +2 more sources
Hypomorphy of graphs up to complementation
, 2008 13International audienceLet $V$ be a set of cardinality $v$ (possibly infinite). Two graphs $G$ and $G'$ with vertex set $V$ are {\it isomorphic up to complementation} if $G'$ is isomorphic to $G$ or to the complement $\overline G$ of $G$.
Hamza Si Kaddour +7 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Journal of Language ModellingThis paper proposes a formal analysis of two displacement phenomena in Mandarin Chinese, namely inner topicalisation and focus fronting, capturing their correlational relationships with control and complementation.
Chit-Fung Lam
doaj +1 more source
Frontiers in Genetics, 2019 Cell-to-cell heterogeneity drives a range of (patho)physiologically important phenomena, such as cell fate and chemotherapeutic resistance. The role of metabolism, and particularly of mitochondria, is increasingly being recognized as an important ...
Juvid Aryaman +6 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source