Results 201 to 210 of about 168,680 (293)

Systematic design of auxotrophic strains and media conditions to probe metabolic functions in E. coli. [PDF]

PLoS Comput Biol
Mohammadbeygi R, Suthers PF, Chung FY, Pfleger BF, Maranas CD.   +4 more
europepmc   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Multifaceted effects of <i>galU</i> deletion on phenotype and virulence of <i>Pseudomonas aeruginosa in vitro</i> and <i>in vivo</i>. [PDF]

Virulence
Yu J, Wang J, Yang Y, Sun L, Hu X, Nie T, Yang X, Wang X, Li C, You X.   +9 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

A versatile plasmid platform for auxotrophic complementation in attenuated Mycobacterium bovis BCG. [PDF]

Mol Biol Rep
Madruga AB, Nogueira JD, Maia MAC, de Oliveira NR, Ehlert ME, Ferreira VG, Pacheco BS, Seixas FK, Collares TV, Acosta IB, Varela AS, Dellagostin OA, Bohn TLO.   +12 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Releasing the brake on plasma membrane H+-ATPases alters systemic defense. [PDF]

Plant Physiol
Chen Y, Xu B.
europepmc   +1 more source

CodY constrains β-cypermethrin degradation by regulating physiological adaptation and soil ecological performance in <i>Bacillus cereus</i> GW-01. [PDF]

Synth Syst Biotechnol
Lei Y, Tang Y, Wei E, He M, Xu B, Liao Y, Li W, Wang Y, Wang Y, Wang S, Zhao J.   +10 more
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

<i>Brucella</i> deploys multiple type IV effectors that simultaneously control bacterial survival and host inflammatory cell death. [PDF]

Virulence
Sun D, Zhang M, Wu Y, Dai E, Fan X, Zhao Y, Ding J.   +6 more
europepmc   +1 more source