Results 81 to 90 of about 1,682,624 (248)

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Environmental agreements : strategic complements and transnational cooperation [PDF]

open access: yes, 2017
Mitigation of greenhouse gasses will have to increase strongly in order to avoid disastrous consequences. This work uses game theory to explore promising negotiation structures. Adaptation can be a chance for negotiations on emissions. Adaptation-driven strategic complements can induce countries to act quasi-cooperatively if they have a Stackelberg ...
openaire  

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

open access: yesFEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan   +4 more
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

open access: yesFEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Complementizer-Alternation in Creole Languages: New Evidence for Spec-Head Agreement

open access: yes, 2015
The topic of this paper is the ki/ma alternation in Cape Verdean Creole (henceforth, CVC) with a focus on the behavior of ki within wh-questions. We argue that ki is a morphosyntactic reflex of Q-agreement between [uQ] on C and a wh-phrase, supporting spec-head agreement in Chomsky (1991), contra the probe-goal agreement system in Chomsky (2000). In so
Baptista, Marlyse, Obata, Miki
openaire   +2 more sources

Comparing the paths of Hedgehog release in artificial and natural settings

open access: yesFEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Complementizer doubling and subject extraction in Italo-Romance

open access: yes, 2018
In this article I analyze the complementizer doubling construction attested in some early and modern Italo-Romance varieties, where a preposed (clausal or non clausal) constituent associated to the selected clause appears in the embedded left periphery ...
Munaro, Nicola, Nicola Munaro
core   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

open access: yesFEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini   +3 more
wiley   +1 more source

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