Results 31 to 40 of about 294,344 (225)

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Abrogation of the alternative complement pathway by targeted deletion of murine factor B [PDF]

Proceedings of the National Academy of Sciences, 1997
To investigate the role of complement protein factor B (Bf) and alternative pathway activity in vivo , and to test the hypothesized potential genetic lethal effect of Bf deficiency, the murine Bf gene was interrupted by exchange of exon 3 through exon 7 (including the factor D cleaving site ...
M, Matsumoto, W, Fukuda, A, Circolo, J, Goellner, J, Strauss-Schoenberger, X, Wang, S, Fujita, T, Hidvegi, D D, Chaplin, H R, Colten   +9 more
openaire   +2 more sources

Complementizer Drop And IP Complementation in Japanese

, 2000
The main purpose of the present paper is to provide a principled account for a phenomenon called "Complementizer Drop" in the dialects of Japanese and its related phenomena in teens of the head-raising approach without recourse to the ECP or GB-type ...
Fukuda, Minoru
core   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Complementation of Vaccinia Virus Deleted of the E3L Gene by Mutants of E3L

Virology, 1997
Vaccinia virus devoid of its E3L gene is sensitive to treatment of RK-13 cells with interferon-alpha and fails to replicate or form plaques in HeLa cells. In order to determine function of the E3L gene, vaccinia virus recombinants were constructed by inserting mutant E3L genes or a gene coding for an alternative dsRNA-binding protein into virus deleted
Shors, Teri, Kibler, Karen V., Perkins, Kim B., Seidler-Wulff, Renee, Banaszak, Matthew P., Jacobs, Bertram L.   +5 more
openaire   +2 more sources

Genetic elements for selection, deletion mutagenesis and complementation inFrancisellaspp. [PDF]

FEMS Microbiology Letters, 2008
Francisella novicida is a gram-negative pathogen that can induce disease in mice that mimics human tularemia, and is nearly identical to Francisella tularensis at the genomic level. In this work a number of antibiotic marker cassettes that incorporate a strong F. novicida promoter is constructed, which greatly enhances selection in F.
Jagjit S, Ludu, Eli B, Nix, Barry N, Duplantis, Olle M, de Bruin, Larry A, Gallagher, Laura M, Hawley, Francis E, Nano   +6 more
openaire   +2 more sources

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

KoMiRe PL Experiment 1 (Relative pronoun vs. relative complementizer)

, 2022
Experiment 1 will investigate the influence of two relativizing strategies in Polish (relative pronoun vs. relative complementizer) on the processing of an agreement chain in constructions with relative clauses, specifically when the relativized head is ...
Ewa Trutkowski, André Meinunger, Piotr Gulgowski   +2 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source