Results 71 to 80 of about 3,490,978 (179)

Deciphering the Medicinal Chemistry Aspects of Akt Inhibitors for the Management of Cancer: Structure–Activity Relationship Frameworks, Landscapes, and Optimization Approaches

open access: yesChemistry &Biodiversity, Volume 23, Issue 9, September 2026.
This review majorly describes the systematic development of Akt inhibitors involving numerous heterocyclic scaffolds along with their structure activity relationships to explore anticancer therapeutic strategies. ABSTRACT The Akt pathway is dysregulated in cancer, leading to proliferation, decreased apoptosis, and metastasis, and hence is a major ...
Mayur S. Dhangar, Mahesh B. Palkar
wiley   +1 more source

Complete Androgen Insensitivity Syndrome

open access: yes, 2018
Objective To determine whether androgen receptors affect the fatty acid profiles of neutral and polar lipids in human meibomian gland secretions. Methods Meibomian gland secretion samples were obtained from both eyes of (1) women with complete ...
Dana, Reza   +4 more
core   +1 more source

Challenges in clinical and laboratory diagnosis of androgen insensitivity syndrome: a case report

open access: yesJournal of Medical Case Reports, 2011
Introduction Androgen is a generic term usually applied to describe a group of sex steroid hormones. Androgens are responsible for male sex differentiation during embryogenesis at the sixth or seventh week of gestation, triggering the development of the ...
Silva Daniela M   +2 more
doaj   +1 more source

A Likely Diagnosis of Familial Partial Androgen Insensitivity Syndrome in Three 46, XY Siblings With Ambiguous Genitalia: A Case Series

open access: yesClinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Familial partial androgen insensitivity syndrome is a rare cause of 46, XY disorder of sex development. It includes marked phenotypic variability, even among siblings. Persistent undervirilization despite normal androgen levels should prompt early multidisciplinary evaluation and counseling, especially where genetic testing is limited.
Tayyeb Ali   +10 more
wiley   +1 more source

Insensibilidade androgênica completa e hérnia inguinal: relato de 3 casos. [PDF]

open access: yes, 1999
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Departamento de Pediatria, Curso de Medicina, Florianópolis ...
Queirós, Raquel Campos Galvão de
core  

A Two‐Stage Hybrid Feature Selection and Ensemble Learning Framework With Explainable AI for Accurate PCOS Prediction

open access: yesHealth Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Polycystic ovary syndrome (PCOS) is the most prevalent endocrine ailment impacting women of reproductive age, distinguished by ongoing imbalances of hormones that lead to the growth of various ovarian cysts alongside other health issues.
Md. Rakibul Hasan Efty   +4 more
wiley   +1 more source

Pesticide Residues, Gut Microbiota, and Gastrointestinal Outcomes: A Scoping Review of Human Evidence

open access: yesComprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 5, September 2026.
ABSTRACT Vegetables anchor healthy‐diet recommendations yet are the principal nonoccupational route by which residues of organophosphate (OP), pyrethroid, neonicotinoid, organochlorine (OC), and glyphosate herbicide enter the diet, with the gut microbiota a plausible mediator linking these residues to functional gastrointestinal (GI) and inflammatory ...
Chengqian Ye   +3 more
wiley   +1 more source

Complete androgen insensitivity syndrome: Dilemmas for further management after gonadectomy

open access: yesJournal of Human Reproductive Sciences, 2019
Complete androgen insensitivity syndrome is a rare condition, wherein a genetic male is phenotypically female and is raised as a female. Treatement requires timely gonadectomy, need for long term hormonal replaceent therapy, psycological and genetic ...
Pratibha Singh   +3 more
doaj   +1 more source

Three siblings with complete androgen insensitivity syndrome [PDF]

open access: yes, 2013
A 27-year old woman presented with primary amenorrhoea and infertility. On examination, she was found to have palpable inguinal gonads, normal female external genitalia, a blind-ending vagina with no cervix, almost complete absence of axillary and pubic ...
Kemp, T
core  

Identification of a critical novel mutation in the exon 1 of androgen receptor gene in 2 brothers with complete androgen insensitivity syndrome.

open access: yes, 2009
Complete androgen insensitivity syndrome is an X-linked inherited disorder caused by mutations in the androgen receptor (AR) gene. Using polymerase chain reaction single-strand DNA conformational polymorphism and DNA sequencing, we identified a novel ...
Falah M   +4 more
core   +2 more sources

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