Results 141 to 150 of about 3,414,694 (256)

Large Language Model Performance on Multistep Clinical Cases: Comparative Study Across Question and Case Levels. [PDF]

JMIR Med Educ
Cha J, Zhao Y, Zong H.
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Development of Pharmabiotic Gel-Serums with <i>Lacticaseibacillus casei</i> Postbiotics and Paraprobiotics Using Chitosan and Carbopol. [PDF]

Gels
Soyer P, Öztürk AA.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Impacts of volumetric vs. anatomical accuracies in GTV segmentation for nasopharyngeal carcinoma: a consensus-guideline-based study. [PDF]

Front Med (Lausanne)
Lu J, Li Y, Yu Y, Guo L, Shao Y, Zhang C, Lin Z, Gan Y.   +7 more
europepmc   +1 more source

Detection of transaction consistency problems in microservices

Tese de Mestrado, Engenharia Informática, 2024, Universidade de Lisboa, Faculdade de CiênciasThe widespread adoption of microservices architecture in modern software development has introduced significant challenges in maintaining data consistency across
Silva, André Filipe dos Santos
core  

On consistency of reward allocation rules in sequencing situations [PDF]

In this paper we consider the equal gain splitting rule and the split core. Both are solution concepts for sequencing situations and were introduced by Curiel, Pederzoli and Tijs (1989) and Hamers, Suijs, Tijs and Borm (1994) respectively.
Tijs, S.H., Suijs, J.P.M., Hamers, H.J.M.   +2 more
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Device Performance During Simulated Emergency Infant Oropharyngeal Contamination: Effects of Airway Anatomy and Fluid Consistency. [PDF]

Children (Basel)
Jindal R, Anderson R, Madhok M, DeFor T, Belani K.   +4 more
europepmc   +1 more source