Results 151 to 160 of about 1,988,584 (327)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Konsep Harga Jual Kejujuran: Meraih Keuntungan Menggapai Kemaslahatan

Jurnal Akuntansi Multiparadigma, 2011
Honesty Based Selling Price Concept: Achieving Gain Reaching Goodness. This article aims to reconstruct honesty-based selling price concept in Islam. The research involved owners and management of YDT, Kopontren DT in Bandung, Charni’s Productions in ...
Alimuddin, Iwan Triyuwono, Gugus Irianto, Grahita Chandararin   +3 more
doaj  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

AI Agents-as-Judge: Automated Assessment of Accuracy, Consistency, Completeness and Clarity for Enterprise Documents [PDF]

Sudip Dasgupta, Shankar, Himanshu
openalex   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The Completeness of Quantum Mechanics and the Determinateness and Consistency of Intersubjective Experience: Wigner's Friend and Delayed Choice [PDF]

, 2019
Michael Silberstein, W. M. Stuckey
openalex   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The impact of clinical manifestations on the prognosis of diffuse large B-cell lymphoma. [PDF]

Ther Adv Hematol
Wang S, Xu X, Ma Y, Qian S, Tang L, Sun L, Shen Z, Ye H, Qian H, Jiang S, Zhou S.   +10 more
europepmc   +1 more source

Consistency, completeness and external validity of ethnicity recording in NHS primary care records: a cohort study in 25 million patients’ records at source using OpenSAFELY [PDF]

The OpenSAFELY Collaborative, Colm Andrews, Rohini Mathur, Jon Massey, Robin Park, Helen J Curtis, Lisa Hopcroft, Amir Mehrkar, Seb Bacon, George Hickman, Rebecca Smith, David H. Evans, Tom Ward, Simon Davy, Peter Inglesby, Iain Dillingham, Steven Maude, Thomas O’Dwyer, Ben Butler-Cole, Lucy Bridges, Chris Bates, John Parry, Frank Hester, Sam Harper, Jonathan Cockburn, Ben Goldacre, Brian MacKenna, Laurie A. Tomlinson, Alex J Walker, William Hulme   +29 more
openalex   +1 more source