Results 151 to 160 of about 3,414,694 (256)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Clinical Utility and Patient-Level Analysis of IDDSI Level 1 (Slightly Thick) in Oropharyngeal Dysphagia: A Strategy to Mitigate Over-Thickening and Support Hydration. [PDF]

Nutrients
Kim JW, Choi SY, Lee JW, Jang SH, Han SH, Park JH, Yun YJ.   +6 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

DFRSeisNet: Fluctuation-Prior-Regularized Background Noise Attenuation for Seismic Signal Denoising. [PDF]

Sensors (Basel)
Deng F, Pang L, Wang S, Peng W.
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Cartoon style generation of animated image scenes based on improved GAN and RetNet. [PDF]

PLoS One
Jin Z, Yang L.
europepmc   +1 more source

Incomplete pairwise comparison and consistency optimization [PDF]

This paper proposes a new method for calculating the missing elements of an incomplete matrix of pairwise comparison values for a decision problem. The matrix is completed by minimizing a measure of global inconsistency, thus obtaining a matrix which is ...
Silvio Giove, Michele Fedrizzi
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A novel fluoride tray-assisted workflow for artificial intelligence-driven automated maxillary gingival segmentation on cone beam CT. [PDF]

Dentomaxillofac Radiol
Papasratorn D, Gracea RS, Fontenele RC, Jacobs R.   +3 more
europepmc   +1 more source

When Allais meets Ulysses: Dynamic Consistency and the Certainty Effect [PDF]

We report experimental findings about subjects’ behavior in dynamic decision problems involving multistage lotteries with different timings of resolution of uncertainty. Our within subject design allows us to study violations of the independence axiom in
Antoine Nebout, Dimitri Dubois
core