Results 61 to 70 of about 305,530 (267)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

On clique-complete graphs

Discrete Mathematics, 1998
Let \(G\) be a simple graph. The clique graph \(K(G)\) is the intersection graph of the maximal cliques of \(G\). A vertex in \(G\) is universal if it is adjacent to all other vertices in \(G\). The \(n\)th iterated clique graph of \(G\) is defined by \(K^{(n)}= K(K^{n-1} (G))\) and \(G\) is \(n\)-convergent if \(K^n (G)\) is isomorphic to the one ...
Cláudio Leonardo Lucchesi, Célia Picinin de Mello, Jayme Luiz Szwarcfiter   +2 more
openaire   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

The m-bipartite Ramsey number of the K2,2 versus K6,6 [PDF]

Contributions to Mathematics, 2022
Yaser Rowshan
doaj   +1 more source

Enumeration of Matchings in the Incidence Graphs of Complete and Complete Bipartite Graphs

SIAM Journal on Discrete Mathematics, 2002
Summary: If \(G=(V,E)\) is a graph, the incidence graph \(I(G)\) is the graph with vertices \(V\cup E\) and an edge joining \(v\in V\) and \(e\in E\) when and only when \(v\) is incident with \(e\) in \(G\). For \(G\) equal to \(K_{n}\) (the complete graph on \(n\) vertices) or \(K_{n,n}\) (the complete bipartite graph on \(n + n\) vertices), we ...
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Commuting graphs of gamma rings

Open Mathematics
Let M be a non-commutative gamma ring and ZΓM ${Z}_{{\Gamma}}\left(M\right)$ denote the center of the gamma ring M. The vertices a and b are consecutive if a ≠ b and aαb = bαa for every α ∈ Γ, with vertices taken from the set M−ZΓM $M-{Z}_{{\Gamma ...
Arslan Okan
doaj   +1 more source