Results 51 to 60 of about 102,220 (261)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
A Fixed Point Theorem for Multivalued Mappings with δ-Distance
Abstract and Applied Analysis, 2014 We mainly study fixed point theorem for multivalued mappings with δ-distance using Wardowski’s technique on complete metric space. Let (X,d) be a metric space and let B(X) be a family of all nonempty bounded subsets of X.
Özlem Acar, Ishak Altun
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Mathematics, 2019 In the present article, the notion of αH-ψH-multivalued contractive type mappings is introduced and some fixed point results in complete metric spaces are studied. These theorems generalize Nadler’s (Multivalued contraction mappings, Pac. J.
Pooja Dhawan +2 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
The metric completion of the Riemannian space of Kähler metrics
, 2014 Let $X$ be a compact Kähler manifold and $\a \in H^{1,1}(X,\R)$ a Kähler class. We study the metric completion of the space $\HH_\a$ of Kähler metrics in $\a$, when endowed with the Mabuchi $L^2$-metric $d$. Using recent ideas of Darvas, we show that the metric completion $(\overline{\HH}_\a,d)$ of $(\HH_\a,d)$ is a CAT(0) space which can be identified
openaire +3 more sources
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
A Mizoguchi–Takahashi Type Fixed Point Theorem in Complete Extended b-Metric Spaces
Mathematics, 2019 In this paper, we prove a new fixed point theorem for a multi-valued mapping from a complete extended b-metric space U into the non empty closed and bounded subsets of U, which generalizes Nadler’s fixed point theorem.
Nayab Alamgir +3 more
doaj +1 more source