Results 71 to 80 of about 102,220 (261)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

A remark on Rhoades fixed point theorem for non-self mappings

International Journal of Mathematics and Mathematical Sciences, 1993
Let X be a Banach space, K a non-empty closed subset of X and T:K→X a mapping satisfying the contractive definition (1.1) below and the condition T(∂K)⫅K. Then T has a unique fixed point in K.
Ljubomir B. ciric
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

BEBERAPA SIFAT PEMETAAN C-KONTRAKTIF DI RUANG METRIK PARSIAL DAN TITIK TETAPNYA

E-Jurnal Matematika
Partial metric space is a generalization of ordinary metric space, in partial metric space the axiom d(x,x) is no longer necessarily zero. Partial metric space was first introduced in 1994, since then many researchers have continued to learn about ...
ROSANTI WAHIDATUSSOLIHAH, QURRATUL AINI, MARWAN MARWAN   +2 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

ON Modified (α-η)-Contractive Mappings

Abstract and Applied Analysis, 2014
Hussain et al. (2013) established new fixed point results in complete metric space. In this paper, we prove fixed point results of α-admissible mappings with respect to η, for modified contractive condition in complete metric space.
Marwan Amin Kutbi, Muhammad Arshad, Aftab Hussain   +2 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Fixed Point Theorem in Fuzzy Metric Space

Fuzzy Optimization and Modeling
In this present work, we prove fixed point theorem for contractive mapping F: X--X in fuzzy metric spaces that have a nonempty F− invariant complete subspace E, then prove the uniqueness the fixed point in E.
Samaneh Ghods
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Fixed Points Results in G-Metric Spaces

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2019
  In this paper, the concept of contraction mapping on a -metric space is extended with a consideration on local contraction.  As a result, two fixed point theorems were proved for contraction on a closed ball in a complete -metric space.
Salwa Salman Abed, Anaam Neamah Faraj
doaj   +1 more source