Results 281 to 290 of about 270,006 (355)

The Critical Role of Enhanced OXPHOS and Mitochondrial Hyperpolarization in Simulated Microgravity‐Induced Oocyte Maturation Arrest

Advanced Science, EarlyView.
Simulated microgravity induces distinct mitochondrial hyperactivation patterns‐elevated OXPHOS and MMP‐which accelerate meiosis without SAC failure but delays MTOC coalescence, leading to spindle defects and meiotic arrest. Prolonging M‐phase restores MTOC assembly and oocyte maturation.
Lei Ge, Yuqing Gao, Feifei Du, Chiyuan Ma, Tianxia Xiao, Yali Yang, Xiaohua Lei, Jian V. Zhang   +7 more
wiley   +1 more source

The complete mitochondrial genome of <i>Leuciscus chuanchicus</i> (Kessler, 1876) (Cypriniformes: Cyprinidae). [PDF]

Mitochondrial DNA B Resour
Wang T, Song F, Yang Z, Su Z, Shi X, Zhang Y, Lv B, Du Y.   +7 more
europepmc   +1 more source

Conserved PCR Primer Set Designing for Closely-Related Species to Complete Mitochondrial Genome Sequencing Using a Sliding Window-Based PSO Algorithm

, 2011
Cheng‐Hong Yang, Hsueh‐Wei Chang, Chang‐Hsuan Ho, Yii-Cheng Chou, Li‐Yeh Chuang   +4 more
openalex   +2 more sources

PRMT3‐Mediated H4R3me2a Promotes Primary Age‐Related Tauopathy by Driving Tau Hyperphosphorylation in Neuron

Advanced Science, EarlyView.
This study identifies PRMT3‐mediated H4R3me2a as a critical driver of tau hyperphosphorylation in primary age‐related tauopathy. Mechanistic insights reveal that the PRMT3/H4R3me2a/miR‐448 axis suppresses IGF1R expression via epigenetic regulation, further dysregulating the PI3K/AKT/GSK3β pathway.
Haotian Liu, Xinnan Liu, Fengyuan Tian, Yashuang Chen, Jingying Li, Xue Wang, Wenying Qiu, Xia Wang, Chao Ma, Wei Ge   +9 more
wiley   +1 more source

Barbastellacaspica (Chiroptera, Vespertilionidae) in China: first record and complete mitochondrial genome. [PDF]

Zookeys
Wang ZY, Abduriyim S.
europepmc   +1 more source

A Network‐Driven Framework for Drug Response Precision Prediction of Acute Myeloid Leukemia

Advanced Science, EarlyView.
A network‐based precision medicine platform, named NetAML is offered for personalized treatment of AML. It combines network analysis and machine learning to develop 87 models predicting drug sensitivity for clinical drugs. NetAML identifies interpretable gene signatures that drive differential drug responses, enabling the prediction of individual ...
Yinyin Wang, Rui Liu, Yinnan Zhang, Xiang Luo, Chengzhuang Yu, Shentong Fang, Ninghua Tan, Jing Tang   +7 more
wiley   +1 more source

The Complete Mitochondrial Genome of <i>Squalus cubensis</i> and Comparative Mitogenomics and Phylomitogenomics of the Family Squalidae. [PDF]

Ecol Evol
Skufca K, Baeza JA.
europepmc   +1 more source

Engineering Adenine Deaminase TadA for Precise and PAM‐Flexible Point Mutagenesis and Gradient‐Tuning Endogenous Protein Design

Advanced Science, EarlyView.
Base editing enables precise nucleotide substitutions but limited by bystander editing. This study engineers plant base editors by fusing optimized TadA variants with PAM‐flexible SpRY nickase, enabling A‐to‐G, C‐to‐T, and dual‐base conversions in a highly condensed window (≤3 nucleotides). Additionally, TadDBE (TadA Dual‐Base Editor)‐mediated directed
Kangli Sun, Si Cheng, Nan Chai, Jianing Mi, Ruixiang Zhang, Qian Qian, Zhiye Zheng, Ke Chen, Dongchang Zeng, Xin Peng, Mengyuan Shen, Degui Zhou, Qinlong Zhu, Qi Liu, Jiantao Tan   +14 more
wiley   +1 more source

Complete Mitochondrial Genome of <i>Chlorogomphus papilio</i> (Odonata: Anisoptera: Chlorogomphidae) and Phylogenetic Analyses. [PDF]

Biology (Basel)
Jin X, Lin X, Wang S, Fang J.
europepmc   +1 more source

Anti‐Icing Organogel Enables Quasi‐Homogeneous Supercooling Preservation of Mouse Hearts

Advanced Science, EarlyView.
An organogel interface with a large energy barrier for ice nucleation is proposed to enable a quasi‐homogeneous supercooling preservation for organs. This method does not rely on cryoprotectant agents or machine perfusion and can double the ex vivo storage time of mouse hearts.
Junhao Li, Wei Wang, Chenghao Li, Lintao Kuang, Zhi Huang, Xing Chen, Zhenghao Guo, Kang Liu, Jinping Liu   +8 more
wiley   +1 more source