Results 51 to 60 of about 7,985,327 (252)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Prediction of pathological complete response and prognosis in patients with neoadjuvant treatment for triple-negative breast cancer [PDF]

, 2018
Background It has been reported that pathological complete response is an important surrogate marker for disease-free survival and overall survival in patients with triple-negative breast cancer.
Häberle, Lothar, Erber, Ramona, Alexander Hein, Paul Gass, Hein, Alexander, Lux, Michael P., Beckmann, Matthias W., Wachter, David L., Hartmann, Arndt, Gass, Paul, Wunderle, Marius, Michael P. Lux, Fiessler, Cornelia, Matthias W. Beckmann, Claudia Rauh, Marius Wunderle, Schulz-Wendtland, Rüdiger, Mayada R. Bani, Pretscher, Jutta, Bani, Mayada R., Rauh, Claudia, Rüdiger Schulz-Wendtland, Peter A. Fasching, Arndt Hartmann, Jutta Pretscher, Fasching, Peter A., Lothar Häberle, Ramona Erber, Cornelia Fiessler, David L. Wachter   +29 more
core   +1 more source

Treatment Patterns and Outcomes of Ovarian Cancer in Different Centres of Karachi

Pakistan Armed Forces Medical Journal
Objective: To evaluate the treatment pattern i.e. either upfront surgery followed by adjuvant chemotherapy or upfront neoadjuvant chemotherapy followed by surgery and outcomes of advance ovarian cancer in different hospitals of Karachi.
Perwasha Kerio, Ghulam Haider, Khalil Ahmed, Saima Zahoor, Hina Perveen, Muhammad Hayat   +5 more
doaj   +1 more source

18F-FDG PET Radiomics as Predictor of Treatment Response in Oesophageal Cancer: A Systematic Review and Meta-Analysis

Frontiers in Oncology, 2022
The best treatment strategy for oesophageal cancer patients achieving a complete clinical response after neoadjuvant chemoradiation is a burning topic. The available diagnostic tools, such as 18F-FDG PET/CT performed routinely, cannot accurately evaluate
Letizia Deantonio, Letizia Deantonio, Maria Luisa Garo, Gaetano Paone, Maria Carla Valli, Stefano Cappio, Davide La Regina, Davide La Regina, Marco Cefali, Maria Celeste Palmarocchi, Alberto Vannelli, Sara De Dosso, Sara De Dosso   +12 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

“Watch and wait” approach in rectal cancer patients following complete clinical response to neoadjuvant chemoradiotherapy does not compromise oncologic outcomes

The Turkish Journal of Gastroenterology, 2019
Background/Aims: Although standart treatment for non-metastatic locally advanced rectal cancer includes neoadjuvant chemoradiation followed by surgical resection, patients who have achieved complete clinical response can be followed up without surgery ...
Gürel Neşşar, Ali Eba Demirbağ, Hasan Cem Mısırlıoğlu, Semih Sezer   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Breast cancer: Monitoring response to neoadjuvant chemotherapy using Tc-99m sestamibi scintimammography [PDF]

, 2003
Background: Aim of the study was to assess the value of scintimammography using Tc-99m sestamibi in the evaluation of tumor response to neoadjuvant chemotherapy.
Sommer, H., Keßler, M., Tiling, R., Brinkbäumer, K., Hahn, K., Untch, M., Linke, R.   +6 more
core   +1 more source