Results 91 to 100 of about 1,501,714 (262)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

THE BEST SOLUTION FOR INEQUALITIES OF A O CROSS X LOWER THAN X FROM B O DOT X USING HIGH MATRIX RESIDUATION OF IDEMPOTENT SEMIRING

Jurnal Sains Dasar, 2017
A complete idempotent semiring has a structure which is called a complete lattice. Because of the same structure as the complete lattice then inequality of the complete idempotent semiring can be solved a solution by using residuation theory.
Eka Susilowati, Ari Suparwanto
doaj  

A gamified solution to promote positive habits in children and adolescents with Intellectual Disabilities

Journal on Interactive Systems
This paper outlines the development and assessment of a gamified solution called Task Complete, designed to enhance productivity and promote positive habits, particularly among individuals with Intellectual Disabilities.
Pedro Afonso F. Michalichem, Leonardo Tórtoro Pereira, Kamila Rios da Hora Rodrigues   +2 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

A Dynamical Analysis and New Traveling Wave Solution of the Fractional Coupled Konopelchenko–Dubrovsky Model

Fractal and Fractional
The main object of this paper is to study the traveling wave solutions of the fractional coupled Konopelchenko–Dubrovsky model by using the complete discriminant system method of polynomials.
Jin Wang, Zhao Li
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Toward a More Complete OMR Solution

CoRR
Optical music recognition (OMR) aims to convert music notation into digital formats. One approach to tackle OMR is through a multi-stage pipeline, where the system first detects visual music notation elements in the image (object detection) and then assembles them into a music notation (notation assembly).
Guang Yang 0046, Muru Zhang, Lin Qiu, Yanming Wan, Noah A. Smith   +4 more
openaire   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Explicit solutions of the generalized Kudryashov’s equation with truncated M-fractional derivative

Scientific Reports
The main purpose of this article is to study the generalized Kudryashov’s equation with truncated M-fractional derivative, which is commonly used to describe the propagation of wide pulses in nonlinear optical fibers.
Musong Gu, Fanming Liu, Jiale Li, Chen Peng, Zhao Li   +4 more
doaj   +1 more source