Results 101 to 110 of about 296,905 (259)

A survey on dilations of projective isometric representations [PDF]

open access: yesSurveys in Mathematics and its Applications, 2009
In this paper we present Laca-Raeburn's dilation theory of projective isometric representations of a semigroup to projective isometric representations of a group [M.Laca and I.Raeburn, Proc. Amer. Math.
Tania-Luminiţa Costache
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Perturbed functional and neutral functional evolution equations with infinite delay in Frechet spaces

open access: yesElectronic Journal of Differential Equations, 2008
This article shows sufficient conditions for the existence of mild solutions, on the positive half-line, for two classes of first-order functional and neutral functional perturbed differential evolution equations with infinite delay.
Mouffak Benchohra, Selma Baghli
doaj  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Bell–Clauser–Horne–Shimony–Holt Behavior Under Quantum Loss and Decoherence

open access: yesCryptography
We present a detailed analysis of the effect of quantum loss and decoherence in the Bell-CHSH scenario. Adopting a device-independent approach, we study the change in the bipartite conditional probability distribution, i.e., the behavior of the realized ...
Ottó Hanyecz   +3 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

A new proof for monotonicity of sandwiched Renyi relative entropy

open access: yes四川大学学报. 自然科学版, 2018
Itis well known that in quantum information quantum relative is monotonically decreasing under the completely positive and trace-preserving maps. For a new proposed sandwiched R\'enyi quantum relative, a map that is linear trace-preserving and whose ...
wang you le, Luo Maokang, DENG Ke
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

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