Results 121 to 130 of about 167,596,152 (287)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

REporting quality of PilOt randomised controlled trials in surgery (REPORTS): a methodological survey protocol

BMJ Open
Introduction The aim of this methodological review is to evaluate the completeness of reporting of surgical pilot and feasibility randomised trials as per the Consolidated Standards of Reporting Trials (CONSORT) extension to randomised pilot and ...
Lehana Thabane, Mohit Bhandari, Sameer Parpia, Keean Nanji, Sophia Zhang, Alex Thabane, Tyler McKechnie, Tania Kazi, Austine Wang, Aristithes G Doumouras, Cagla Eskicioglu   +10 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Coding of completeness of reporting of trial outcomes.

, 2013
Coding of completeness of reporting of trial outcomes.
Michaela F. Kerekes (467992), Beate Wieseler (467990), Natalia Wolfram (467991), Volker Vervölgyi (467993), Marloes Kamphuis (467995), Ulrich Grouven (229230), Natalie McGauran (44782), Petra Kohlepp (467994)   +7 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Completeness of tuberculosis case notification in Ghana: record linkage and capture-recapture analysis of three TB registries

BMC Infectious Diseases
Background In many low and middle-income countries, Tuberculosis (TB) surveillance systems miss out on reporting on detected cases suggesting gaps in the TB case detection and documentation systems.
Mavis Pearl Kwabla, John Humphrey Amuasi, Gerard Krause, William Dormechele, Wisdom Takramah, Gideon Kye-Duodu, Eric Osei, Joyce Der, Frank Baiden, Yaw Adusi-Poku, Fred Newton Binka, Stefanie Castell   +11 more
doaj   +1 more source

Completeness of reporting of quality improvement studies in neonatology is inadequate: a systematic literature survey. [PDF]

BMJ Open Qual, 2021
Hu ZJ, Fusch G, Hu C, Wang JY, El Helou Z, Hassan MT, Mbuagbaw L, El Helou S, Thabane L.   +8 more
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Completeness of reporting for COVID-19 case reports, January to April 2020: a meta-epidemiologic study. [PDF]

CMAJ Open, 2021
Scaffidi MA, Gimpaya N, Li J, Bansal R, Verma Y, Elsolh K, Donn GM, Panjwani A, Khan R, Grover SC.   +9 more
europepmc   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source