Results 111 to 120 of about 1,512,917 (302)

Il programma speculativo

open access: yesRivista di Estetica
The project of speculative thinking cannot ignore the post-speculative intellectual situation. Rather, it must react to it and constitute itself within it.
Gunnar Hindrichs
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A Calling for Standardised Completion Criteria in Weight Management

open access: yes, 2016
Purpose: The criteria for participant completion of a weight management programme (WMP) is arbitrary. Programme commissioners (WMP purchasers) will frequently establish the percentage of attendance that classifies programme completion (e.g.
Pringle, Andy   +5 more
core  

Continuing medical education program completion and influencing factors: a cross-sectional study in Sichuan Province, China

open access: yesFrontiers in Medicine
ObjectivesThis cross-sectional study was designed to explore the completion of continuing medical education (CME) programs and identify the factors influencing their completion.MethodsThe data for this study were generated from the National CME Program ...
Xuedong Liu, Xuedong Liu, Mengliang Ye
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Sand Control Performance Measure System for Full Size Sand Control Screen

open access: yesShiyou jixie, 2018
To meet the sand control requirements of oil and gas well completion and evaluate the sand retaining performance of sand control screen, a set of sand control performance measure system for full size sand control screen was developed.
Wang Yao   +6 more
doaj  

Completeness of Tree Automata Completion.

open access: yes, 2018
We consider rewriting of a regular language with a left-linear term rewriting system. We show a completeness theorem on equational tree automata completion stating that, if there exists a regular over-approximation of the set of reachable terms, then equational completion can compute it (or safely under-approximate it). A nice corollary of this theorem
openaire   +4 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Research and Application of Expandable Tieback Device for Multilateral Well

open access: yesShiyou jixie, 2017
Considering the rare completion technology of current multilateral well and the difficult tieback technology, an expandable tieback device for multilateral well has been developed.
Qi Yamin   +3 more
doaj  

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