Results 121 to 130 of about 51,568 (249)

Precision medicine in cancer: A comprehensive review of advanced cancer diagnosis technologies and personalized treatment strategies

Precision Medical Sciences, EarlyView.
The translational pipeline of precision medicine in clinical oncology. Schematic overview of the individualized cancer care workflow. (1) Input: Patient samples undergo multi‐omic profiling via NGS, single‐cell diagnostics, spatial maps, and epigenetic sequencing.
Asif Jan, Bushra Waheed, Rani Akbar, Daniel Dubwa   +3 more
wiley   +1 more source

How We Simulate Nanopores

Small Methods, EarlyView.
Nanopore technology has revolutionized single‐molecule sensing, yet it suffers from an inherent interpretive challenge. Molecular dynamics has emerged as a go‐to method for determining the relationship between the structure of translocating molecules and the nanopore current signals.
Behzad Mehrafrooz, Xavier Mleziva, Meng Xu, Melika Shekari, Christopher Maffeo, Aleksei Aksimentiev   +5 more
wiley   +1 more source

Clinical and Genetic Analysis of Pediatric Neurodevelopmental Disorders With Complex Chromosomal Rearrangements in Two Cases. [PDF]

Mol Genet Genomic Med
Li J, Fan W, Liu N, Zhang S, Wang P, Gu C, Shu J.   +6 more
europepmc   +1 more source

Russian wheat aphid: a model for genomic plasticity and a challenge to breeders

Insect Science, EarlyView.
Invasive foundress finds suitable habitat and reproduces through pathogenesis. Wingless females produce life offspring quickly, which leads to high population densities. High population densities result in competition, which may induce epigenetic changes and wing development for dispersal.
Astrid Jankielsohn, Vicky L. Tolmay, Marlon‐Schylor Luke le Roux, Lintle Mohase, Mpho S. Mafa, Vittorio F. Nicolis, Eduard Venter, Nicolaas Francois Visser Burger, Anna‐Maria Botha   +8 more
wiley   +1 more source

Evolutionary and Epidemiological Characterization of Multidrug‐Resistant Escherichia coli Isolated From Pangolins in China

Integrative Zoology, EarlyView.
ABSTRACT Malayan pangolin populations have fallen to a critically endangered level, and illegal trafficking of wild pangolins is a global problem. Little is known about antimicrobial‐resistant bacteria (MDRB) harbored by pangolins, although pangolins are frequently consumed as food or used in traditional medicine. In this study, we report for the first
Yawen Wang, Xue Wang, Jianan Zhao, Jun Zeng, Shijia Hu, Fang Ji, Guoying Dong, Hongxuan He, Chengmin Wang   +8 more
wiley   +1 more source

CCRR: a user-friendly platform for analyzing complex chromosomal rearrangements in tumors. [PDF]

Bioinformatics
Liu J, Wang K, Yuan Y, Bao G, Ci H, Liu M, Lyu Y, Tang J, Yang J, Cai H.   +9 more
europepmc   +1 more source

Stable transmission of complex chromosomal rearrangements involving chromosome 1q derived from constitutional chromoanagenesis. [PDF]

Mol Cytogenet, 2019
Gudipati MA, Waters E, Greene C, Goel N, Hoppman NL, Pitel BA, Webley MR, Zou Y.   +7 more
europepmc   +1 more source

Comparisons Between Large‐Scale Genomic Variants and SNPs in Driving Population Divergence and Local Adaptation

Integrative Zoology, EarlyView.
Candidate genes identified from SNPs, indels, and SVs exhibited limited shared genes, suggesting that diverse variant types capture complementary aspects of the adaptive landscape. Our results underscore the importance of incorporating multiple types of genomic variation to achieve a more comprehensive understanding of evolutionary processes.
Qianghui Zhu, Hongrui Lv, Yalin Cheng, Shangyu Wang, Dezhi Zhang, Yan Hao, Gang Song, Fumin Lei   +7 more
wiley   +1 more source

From Evolutionary Genomics to Conservation Action: Gibbon as a System for Integrative Primate Genomics

Integrative Zoology, EarlyView.
This review synthesizes gibbon genomic research to propose a framework from evolutionary reconstruction and multidimensional vulnerability assessment to conservation intervention and long‐term dynamic monitoring. We clarify the supporting role of genomic evidence in conservation decision‐making and delineate a practicable pathway for integrating ...
Hangyu Tian, Pengfei Fan, Dongdong Wu
wiley   +1 more source

Preimplantation genetic testing for complex chromosomal rearrangements: clinical outcomes and potential risk factors. [PDF]

Front Genet
Liu D, Chen C, Huang Q, Dong Y, Xu L, Dong M, Zhu Z, Huang L, Wang F, Zhang L, Zhang X, Liu F.   +11 more
europepmc   +1 more source