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What Is a Complex Chromosome Rearrangement?
American Journal of Medical Genetics Part A, 2013No single definition of a complex chromosome rearrangement (CCR) can adequately cover the whole range of possible structural rearrangements. There are highly complex CCRs with multiple breaks that involve three, four or more chromosomes, but there are also CCRs that involve just two chromosomes or even a single chromosome.
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Complex chromosomal rearrangement in a woman with multiple miscarriages
American Journal of Medical Genetics, 1988AbstractWe report on a 23‐yr‐old healthy female with repeated miscarriages and a de novo complex chromosomal rearrangement (CCR) involving chromosomes 1, 2, 5 and 11 with 5 breakpoints. A review of cases reported in the last five yr is provided.
Katrin Kausch +5 more
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A complex rearrangement of chromosome 7 in human astrocytoma
Cancer Genetics and Cytogenetics, 2004Chromosome 7 is a frequent site of cytogenetic aberrations in human astrocytomas. One region that is often targeted in human astrocytomas is on 7p. The U251 human glioblastoma cell line has a region of gain of genetic material on 7p similar to that seen in human astrocytomas.
Anjan, Misra +3 more
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Complex chromosomal rearrangement and multiple spontaneous abortions
Human Genetics, 1986We report on a woman with a balanced complex chromosomal rearrangement (CCR) involving chromosomes 7, 10, and 21. She is the third individual with an apparently de novo CCR to be ascertained by repeated fetal wastage. Both familial and de novo CCRs are associated with recurrent spontaneous abortions.
J L, Gorski +3 more
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A complex balanced chromosomal rearrangement in repeated abortions
Human Genetics, 1987A double balanced reciprocal translocation involving four chromosomes, t(1;19;6;14) (1p11; 19p11; 6q25; 14q21), was found in the phenotypically normal husband in a couple referred because of repeated abortions. Reciprocal translocations, t(6;14), had been transmitted by his mother, his father being apparently homozygous for a translocation comprising ...
A, Barros +5 more
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Heterogeneity of a Constitutional Complex Chromosomal Rearrangement in 2q
Cytogenetic and Genome Research, 2016Complex chromosome rearrangements (CCRs) are unusual structural chromosome alterations found in humans, and to date only a few have been characterized molecularly. New mechanisms, such as chromothripsis, have been proposed to explain the presence of the CCRs in cancer cells and in patients with congenital disorders and/or mental retardation. The aim of
Javier, Del Rey +4 more
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Preimplantation genetic diagnosis for complex chromosome rearrangements
American Journal of Medical Genetics Part A, 2008AbstractComplex chromosome rearrangements (CCR) are structural rearrangements that involve more than two breakpoints. The most common ones involve three chromosomes and three breakpoints, but double translocations can also occur. Theoretically, the potential for chromosome imbalance in the gametes of CCR carriers is higher than for simple ...
T, Escudero +3 more
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Kallmann syndrome associated with complex chromosome rearrangement
American Journal of Medical Genetics, 1993AbstractWe report on a male with Kallmann syndrome (KS) and an apparently balanced complex chromosome rearrangement (CCR): 46,XY,t(3;9)(9;12)(q13.2;q21.2p13;q15). This is the first known report of a CCR in the KS and the second reported case of a definitive autosomal chromosome abnormality with KS.
A C, Casamassima +3 more
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Genes, Chromosomes and Cancer, 1996
In many human cancers the presence of marker chromosomes or unbalanced translocations prevents complete karyotypic analysis. Chromosome microdissection has become an increasingly important method for assessing chromosome rearrangements. However, most studies using chromosome microdissection have been carried out on established cancer cell lines that ...
P, Jonveaux +5 more
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In many human cancers the presence of marker chromosomes or unbalanced translocations prevents complete karyotypic analysis. Chromosome microdissection has become an increasingly important method for assessing chromosome rearrangements. However, most studies using chromosome microdissection have been carried out on established cancer cell lines that ...
P, Jonveaux +5 more
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Complex Chromosomal Rearrangements
Clinical Genetics, 1981Michael R. Creasy, John A. Crolla
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