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IDENTIFICATION OF A COMPLEX CHROMOSOME REARRANGEMENT INNEUROSPORA CRASSA
Canadian Journal of Genetics and Cytology, 1974A complex chromosome rearrangement has been identified using predominantly genetic, but some cytological criteria, in crosses heterozyous for the rearrangement. The rearrangement involves the insertion of a segment of LG I into LG IV in an inverted position with respect to centromere, and a segment of LG IV reciprocally inserted into LG I, possibly in ...
A J, Griffiths, A M, Delange, J H, Jung
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Hybrid Sequencing Characterization of Complex Chromosomal Rearrangements
Complex chromosomal rearrangements (CCRs), defined as structural variants involving more than two chromosomes or multiple breakpoint junctions, are challenging to resolve, and causal mutations often go unnoticed in genome studies. Short-read whole-genome sequencing enables the characterization of rearrangement junctions in unique sequences.Anna, Lindstrand, Jesper, Eisfeldt
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Complex chromosomal rearrangements in patients with chronic myeloid leukemia
Cancer Genetics and Cytogenetics, 2006During progression of chronic myeloid leukemia (CML) from the chronic to the accelerated phase and/or blast crisis, clonal evolution with nonrandom secondary aberrations such as +8, +Ph, i(17q), +19, -Y, +21, +17, and -7 is frequently observed. Complex chromosomal rearrangements (CCR) are rather rare, and the significance and frequency of different ...
Libuse, Babicka +8 more
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Complex chromosomal rearrangements associated with congenital erythrophagocytotic histiocytosis
Clinical Genetics, 1998We describe a patient with a congenital malignant blood disorder and a constitutional de novo chromosomal rearrangement that includes four breakpoints. By conventional cytogenetic analysis an obviously reciprocal balanced translocation with the breakpoints 1p36 and 5q11.2 was diagnosed.
S, Edelhoff +5 more
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Complex chromosome rearrangements in prenatal diagnosis
European journal of human genetics, 2004Complex chromosome rearrangements (CCR) are defined as reciprocal exchanges between three or more chromosomes. It has been observed that most CCR carriers are female. CCr are very rare, with the risk for phenotypic abnormalities increasing as the number of chromosomes and chromosomal breaks involved in the rearrangement increases. The normal phenotypes
Tonković Đurisević, Ivana +5 more
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Complex Chromosomal Rearrangements
Clinical Genetics, 1981Michael R. Creasy, John A. Crolla
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[Complex chromosomal rearrangements: a paradigm for the study of chromosomal instability].
Medecine sciences : M/S, 2014Complex chromosomal rearrangements (CCR) include diverse structural anomalies leading to complex karyotypes which are difficult to interpret. Although karyotype analysis has been able to identify a large number of these rearrangements and to distinguish de novo and familial events, it is the advent of molecular cytogenetic and sequence analysis ...
Vincent, Gatinois +4 more
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Balanced complex chromosome rearrangements: Reproductive aspects. A review
American Journal of Medical Genetics Part A, 2012AbstractThis review examines the reproductive consequences for carriers of a balanced complex chromosome rearrangement (CCR). It is based on an analysis of CCRs in 103 adults referred for reproductive problems, including male infertility. The main focus is on reproductive risks based on data from 84 CCRs.
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Complex chromosomal rearrangements
American Journal of Medical Genetics, 1989openaire +2 more sources