Results 201 to 210 of about 1,254,353 (318)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Complex dynamics of glutamate-induced calcium responses in astrocytes from the nucleus of the solitary tract of mice. [PDF]

Braz J Med Biol Res
Souza MM, Zacharias LR, Leão RM.
europepmc   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Complex dynamics of social learning in groups of wild Arabian babblers. [PDF]

Behav Ecol
Aljadeff N, Keynan O, Lotem A.
europepmc   +1 more source

Complex Dynamics of a Cournot Quantum Duopoly Game with Memory and Heterogeneous Players. [PDF]

Entropy (Basel), 2022
Garcia-Perez L, Grau-Climent J, Alonso-Sanz R, Losada JC.   +3 more
europepmc   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Journal of Applied Nonlinear Dynamics [PDF]

The interdisciplinary journal publishes original and new research results on Applied Nonlinear Dynamics in science and engineering. The aim of the journal is to stimulate more research interest and attention for nonlinear dynamical behaviors and ...
CATANIA, GIUSEPPE
core  

Antibiotic resistance gene sequencing is necessary to reveal the complex dynamics of immigration from sewers to activated sludge. [PDF]

Front Microbiol, 2023
Gibson C, Kraemer SA, Klimova N, Guo B, Frigon D.   +4 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Exploring complex dynamics in nonlinear Riemann wave models using fractional calculus-based expansion. [PDF]

Sci Rep
Mumtaz A, Masood K, Shakeel M, Shah NA.
europepmc   +1 more source