The Rad50 coiled-coil domain is indispensable for Mre11 complex functions. [PDF]
Nat Struct Mol Biol, 2011 The Mre11 complex (Mre11, Rad50 and Xrs2 in Saccharomyces cerevisiae) influences diverse functions in the DNA damage response. The complex comprises the globular DNA-binding domain and the Rad50 hook domain, which are linked by a long and extended Rad50 ...
Hohl M +7 more
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The human Shu complex functions with PDS5B and SPIDR to promote homologous recombination. [PDF]
Nucleic Acids Res, 2019 RAD51 plays a central role in homologous recombination during double-strand break repair and in replication fork dynamics. Misregulation of RAD51 is associated with genetic instability and cancer.
Martino J +7 more
europepmc +2 more sources
Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism. [PDF]
Diabetes Metab J, 2018 Mitochondrial dysfunction is a hallmark of metabolic diseases such as obesity, type 2 diabetes mellitus, neurodegenerative diseases, and cancers. Dysfunction occurs in part because of altered regulation of the mitochondrial pyruvate dehydrogenase complex
Park S +6 more
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Architectures and complex functions of tandem riboswitches [PDF]
RNA Biology, 2022 Riboswitch architectures that involve the binding of a single ligand to a single RNA aptamer domain result in ordinary dose-response curves that require approximately a 100-fold change in ligand concentration to cover nearly the full dynamic range for ...
Madeline E. Sherlock +14 more
doaj +2 more sources
Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C). [PDF]
Open Biol, 2017 The anaphase promoting complex or cyclosome (APC/C) is a large multi-subunit E3 ubiquitin ligase that orchestrates cell cycle progression by mediating the degradation of important cell cycle regulators.
Alfieri C, Zhang S, Barford D.
europepmc +2 more sources
Complex functions with GeoGebra [PDF]
Teaching Mathematics and its Applications, 2016 Complex functions, generally feature some interesting peculiarities, seen as extensions of real functions. The visualization of complex functions properties usually requires the simultaneous visualization of two-dimensional spaces. The multiple Windows of GeoGebra, combined with its ability of algebraic computation with complex numbers, allow the study
Breda, Ana +1 more
openaire +4 more sources
PARP1-produced poly-ADP-ribose causes the PARP12 translocation to stress granules and impairment of Golgi complex functions. [PDF]
Sci Rep, 2017 Poly-ADP-ribose-polymerases (PARPs) 1 and 2 are nuclear enzymes that catalyze the poly-ADP-ribosylation of nuclear proteins transferring poly-ADP-ribose (PAR) polymers to specific residues.
Catara G +8 more
europepmc +2 more sources
Basic and complex cognitive functions in Adult ADHD.
PLoS ONE, 2021 BackgroundMany clinical studies reported deficits in basic and complex cognitive functions in adults with Attention-Deficit/Hyperactivity Disorder (ADHD).
Saleh M H Mohamed +6 more
doaj +2 more sources
Pyruvate kinase M2: A simple molecule with complex functions. [PDF]
Free Radic Biol Med, 2019 Alquraishi M +7 more
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