Envisioning clinical trials as complex interventions. [PDF]
AbstractClinical trials are critical components of modern health care and infrastructure. Trials benefit society through scientific advancement and individual patients through trial participation. In fact, billions of dollars are spent annually in support of these benefits. Despite the massive investments, clinical trials often fail to accomplish their
Stensland KD +4 more
europepmc +3 more sources
From complex social interventions to interventions in complex social systems: Future directions and unresolved questions for intervention development and evaluation [PDF]
Complex systems approaches to social intervention research are increasingly advocated. However, there have been few attempts to consider how models of intervention science, such as the UK’s Medical Research Council complex interventions framework, might be reframed through a complex systems lens.
Moore, Graham +6 more
openaire +6 more sources
Background: Adaptive-style coping strategies are associated with favourable mental health and quality of life outcomes among individuals with chronic disease.
Maya S. Sheth +5 more
doaj +1 more source
Incorporating gender, equity, and human rights into the action planning process: moving from rhetoric to action [PDF]
Background: Mainstreaming of gender, equity, and human rights (GER) is an important focus of the World Health Organization (WHO) and other UN organizations. This paper explores the role of action plans in mainstreaming GER.
Sanjeev Sridharan +4 more
doaj +1 more source
Amongst individuals with a mental health disorder, a comorbid diagnosis of cannabis use disorder (CUD) is associated with numerous adverse consequences, including more severe symptom profiles, poorer treatment response, and reduced psychosocial ...
Justyne D. Rodas +2 more
doaj +1 more source
The role of evaluation in iterative learning and implementation of quality of care interventions
Background: The Lancet Global Health Commission (LGHC) has argued that quality of care (QoC) is an emergent property that requires an iterative process to learn and implement.
Nikhil Shah +4 more
doaj +1 more source
Perinatal depression is the onset of depressive symptoms during pregnancy and up to one year after childbirth. Migrant women are at higher risk of experiencing perinatal depression due to numerous psychosocial stressors related to their experiences. This
Gil Angela Dela Cruz +4 more
doaj +1 more source
Complex Cardiovascular Interventions
Yiannis S. Chatzizisis, MD, PhD
doaj +4 more sources
Where theory and practice of global health intersect: the developmental history of a Canadian global health initiative [PDF]
Objective: This paper examines the scope of practice of global health, drawing on the practical experience of a global health initiative of the Government of Canada – the Teasdale-Corti Global Health Research Partnership Program.
Ibrahim Daibes, Sanjeev Sridharan
doaj +1 more source
Complex Interventions Deserve Complex Evaluations: A Transdisciplinary Approach to Evaluation of a Preventive Personalized Medicine Intervention [PDF]
Non-communicable diseases (NCDs) are the largest cause of disability and death globally. The human and financial costs of NCDs have raised questions of sustainability for many health systems. Personalized, preventive health interventions are an innovative way to address NCDs, but it is difficult to measure their effectiveness using standard evaluation ...
Elise M. Garton +7 more
openaire +3 more sources

