Results 101 to 110 of about 2,169,697 (309)

Emergent approaches to the meta-analysis of multiple heterogeneous complex interventions. [PDF]

, 2015
BACKGROUND: Multiple interventions meta-analysis has been recommended in the methodological literature as a tool for evidence synthesis when a heterogeneous set of interventions is included in the same review—and, more recently, when a heterogeneous set ...
Bonell, Chris, Melendez-Torres, GJ, Thomas, James   +2 more
core   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Evidence synthesis on the occurrence, causes, consequences, prevention and management of bullying and harassment behaviours to inform decision making in the NHS [PDF]

, 2013
Background Workplace bullying is a persistent problem in the NHS with negative implications for individuals, teams, and organisations. Bullying is a complex phenomenon and there is a lack of evidence on the best approaches to manage the problem ...
Burford, Bryan, Carter, Madeline, Cooke, A., Crampton, Paul, Howse, Jenny, Illing, Jan, Morrow, Gill, Thompson, Neill   +7 more
core  

Activity Theory Analysis of Heart Failure Self-Care [PDF]

, 2017
The management of chronic health conditions such as heart failure is a complex process emerging from the activity of a network of individuals and artifacts.
Cornet, Victor, Holden, Richard J., Voida, Stephen   +2 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Medicaid Best Buys: Improving Care Management for High-Need, High-Cost Beneficiaries [PDF]

, 2008
Outlines steps in designing a comprehensive management program for Medicaid beneficiaries with complex needs, including targeting and prioritizing beneficiaries, tailoring interventions, assessing results, and structuring supportive ...

core  

Mass Drug Administration and beyond: how can we strengthen health systems to deliver complex interventions to eliminate neglected tropical diseases? [PDF]

, 2015
Achieving the 2020 goals for Neglected Tropical Diseases (NTDs) requires scale-up of Mass Drug Administration (MDA) which will require long-term commitment of national and global financing partners, strengthening national capacity and, at the community ...
Adams, ER, Bockarie, MJ, Harrison, RA, Hollingsworth, T, Kelly-Hope, LA, Kovacic, V, Lehane, M, Macpherson, EE, Paine, MJI, Reimer, LJ, Torr, SJ   +10 more
core   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Work-related connectivity between Boston Logan international airport and urban communities with high social vulnerability during the COVID-19 pandemic

Tropical Diseases, Travel Medicine and Vaccines
Airports may be high-risk sites for the spread of infectious diseases, including novel respiratory pathogens. While many studies have evaluated the higher burden of COVID-19 among essential workers, few studies have specifically analyzed the links ...
Daniel Begemann, Cristina Alonso, Samantha Bates, Edward T. Ryan, Allison T. Walker, Barry Keppard, Ann Marie Kissel, Flor Amaya, Sowmya R. Rao, Tyler S. Brown, Amir M. Mohareb, Julie H. Levison, Regina C. LaRocque   +12 more
doaj   +1 more source

Dedicated Balloon Techniques for Coronary Calcium Modification

Interventional Cardiology: Reviews, Research, Resources
Coronary calcification represents a significant technical challenge in percutaneous coronary intervention and is associated with worse clinical outcomes.
Max W Maffey, Rodrigo Bagur
doaj   +1 more source