Results 171 to 180 of about 2,169,697 (309)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

TRIPLE C reporting principles for case study evaluations of the role of context in complex interventions. [PDF]

BMC Med Res Methodol, 2023
Shaw SE, Paparini S, Murdoch J, Green J, Greenhalgh T, Hanckel B, James HM, Petticrew M, Wood GW, Papoutsi C.   +9 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Health service access for ethnically underrepresented communities: A scoping review of complex interventions. [PDF]

PLoS One
Pawson JR, Cannon S, Nazeer S, Phillpott C, Kolawole T, Fletcher J, Thomson A, Ross J, Sheehan KJ, Woolhead G.   +9 more
europepmc   +1 more source

Incomplete reporting of complex interventions: a call to action for journal editors to review their submission guidelines. [PDF]

Trials, 2023
Ryan M, Hoffmann T, Hofmann R, van Sluijs E.   +3 more
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Advancing AI-based clinical decision support for complex interventions requires an operationalized framework. [PDF]

Pain Rep
Äng B, Bohman T, Grimby-Ekman A, Ärnlöv J, Thomas I, Nyberg R, Tseli E, Vixner L, Hagelberg M, LoMartire R.   +9 more
europepmc   +1 more source

Long ties accelerate noisy threshold-based contagions

, 2019
Network structure can affect when and how widely new ideas, products, and behaviors are adopted. In widely-used models of biological contagion, interventions that randomly rewire edges (generally making them "longer") accelerate spread.
Eckles, Dean, Mossel, Elchanan, Rahimian, M. Amin, Sen, Subhabrata   +3 more
core  

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Sustainability of Complex Interventions: Recommendations From a Pragmatic Clinical Trial to Manage Cancer Symptoms. [PDF]

Nurs Res
Chlan LL, Ridgeway JL, Ruddy KJ, Austin JD, Mitchell SA, Tofthagen C, Pachman DR, Cheville AL.   +7 more
europepmc   +1 more source