Results 181 to 190 of about 2,169,697 (309)

Conducting Randomized Controlled Trials of Complex Interventions in Prisons: A Sisyphean Task? [PDF]

Front Psychiatry, 2022
Lennox C, Leonard S, Senior J, Hendricks C, Rybczynska-Bunt S, Quinn C, Byng R, Shaw J.   +7 more
europepmc   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Approaches That Simplify Implementation of Complex Interventions in Healthcare System Change: "Scoping Review". [PDF]

J Multidiscip Healthc
Alsaqqa HH.
europepmc   +1 more source

Assessing complex interventions: a systematic review of outcomes used in randomised controlled trials on STI partner notification in high-income countries. [PDF]

BMC Public Health, 2023
Sawras V, Deuffic-Burban S, Préau M, Spire B, Yazdanpanah Y, Champenois K.   +5 more
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Moving Forward With Integrated Care: The Use of Realist Approaches to Understand What Works, How, for Whom and Under Which Circumstances

Public Health Reviews, 2022
Isabelle Peytremann-Bridevaux, Maura MacPhee   +1 more
doaj   +1 more source

Implementing complex interventions to mitigate burnout among qualified healthcare professionals: a realist review protocol. [PDF]

BMJ Open, 2023
Figueiredo S, Koch U, Oliveira E, Ennis-Durstine K.   +3 more
europepmc   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Methods for the health technology assessment of complex interventions: A scoping review. [PDF]

PLoS One
Baghbanian A, Carter D, Merlin T.
europepmc   +1 more source