Results 191 to 200 of about 2,169,697 (309)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Reviewing methodological approaches to dose-response modelling in complex interventions: insights and perspectives. [PDF]

BMC Med Res Methodol
Payne M, Stringer D, Carter B, Hardy A, Emsley R.   +4 more
europepmc   +1 more source

How Stoic principles can help when performing complex interventions. [PDF]

EuroIntervention, 2021
Brilakis ES.
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Applying the framework for developing and evaluating complex interventions to increase family communication about hereditary cancer. [PDF]

PEC Innov, 2023
Cragun DL, Hunt PP, Dean M, Weidner A, Shields AK, Tezak A, Pal T.   +6 more
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Process Evaluations for the Scale-Up of Complex Interventions - a Scoping Review. [PDF]

Int J Integr Care
Rathod L, Heine M, Boateng D, Martens M, van Olmen J, Ku GM, Klipstein-Grobusch K.   +6 more
europepmc   +1 more source

Complex interventions for improving independent living and quality of life amongst community-dwelling older adults: a systematic review and meta-analysis. [PDF]

Age Ageing, 2023
Ho L, Malden S, McGill K, Shimonovich M, Frost H, Aujla N, Ho IS, Shenkin SD, Hanratty B, Mercer SW, Guthrie B.   +10 more
europepmc   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Identifying the active components through the behaviour change techniques taxonomy in complex interventions for people living with multiple long-term health conditions: A systematic review. [PDF]

Br J Health Psychol
Rookes TA, Nimmons D, Frost R, Armstrong M, Tsang WN, Davies L, Ross J, Hopkins J, Mistry M, Taylor SJC, Walters K.   +10 more
europepmc   +1 more source