Results 201 to 210 of about 2,169,697 (309)

Strengthening causal inference from randomised controlled trials of complex interventions. [PDF]

BMJ Glob Health, 2022
Leroy JL, Frongillo EA, Kase BE, Alonso S, Chen M, Dohoo I, Huybregts L, Kadiyala S, Saville NM.   +8 more
europepmc   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Logic models for the evaluation of complex interventions in public health: lessons learnt from a staged development process. [PDF]

BMC Public Health
Voss S, Bauer J, Coenen M, Jung-Sievers C, Moore G, Rehfuess E.   +5 more
europepmc   +1 more source

What Are Complex Interventions in Suicide Research? Definitions, Challenges, Opportunities, and the Way Forward. [PDF]

Int J Environ Res Public Health, 2022
Krishnamoorthy S, Mathieu S, Ross V, Armstrong G, Kõlves K.   +4 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Optimizing Study Design for Evaluating Complex Interventions: An Example of a Feasibility Study in Person-Centered and Integrated Chronic Disease Care in Dutch General Practice. [PDF]

Int J Integr Care
Raaijmakers LHA, Schermer TR, van Bommel HE, Vercoulen JH, van Loenen T, Bischoff EWMA.   +5 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Impact of complex interventions on antibacterial therapy and etiological diagnostics in community-acquired pneumonia: a 12-month pre- and post-intervention study. [PDF]

Front Pharmacol
Ablakimova N, Rachina S, Smagulova G, Vlasenko A, Mussina A, Zhylkybekova A, Yessenzhulova A, Koshmaganbetova GK, Iztleuov Y.   +8 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

A qualitative study to understand the challenges of conducting randomised controlled trials of complex interventions in metastatic colorectal cancer. [PDF]

Trials
McKigney N, Seligmann J, Twiddy M, Bach S, Mohamed F, Fearnhead N, Brown JM, Harji DP.   +7 more
europepmc   +1 more source