Results 51 to 60 of about 438,100 (274)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Geometry of conformal vector fields

Arab Journal of Mathematical Sciences, 2017
It is well known that the Euclidean space (Rn,〈,〉), the n-sphere Sn(c) of constant curvature c and Euclidean complex space form (Cn,J,〈,〉) are examples of spaces admitting conformal vector fields and therefore conformal vector fields are used in ...
Sharief Deshmukh
doaj   +1 more source

Local normal forms for c-projectively equivalent metrics and proof of the Yano-Obata conjecture in arbitrary signature. Proof of the projective Lichnerowicz conjecture for Lorentzian metrics [PDF]

, 2015
Two K\"ahler metrics on a complex manifold are called c-projectively equivalent if their $J$-planar curves coincide. These curves are defined by the property that the acceleration is complex proportional to the velocity.
Bolsinov, Alexey V., Matveev, Vladimir S., Rosemann, Stefan   +2 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

RC-positive metrics on rationally connected manifolds

Forum of Mathematics, Sigma, 2020
In this paper, we prove that if a compact Kähler manifold X has a smooth Hermitian metric $\omega $ such that $(T_X,\omega )$ is uniformly RC-positive, then X is projective and rationally connected. Conversely, we show that, if a projective
Xiaokui Yang
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Solutions to $ar{partial}$-equations on strongly pseudo-convex domains with $L^p$-estimates

Electronic Journal of Differential Equations, 2004
We construct a solution to the $ar{partial}$-equation on a strongly pseudo-convex domain of a complex manifold. This is done for forms of type $(0,s)$, $sgeq 1 $, with values in a holomorphic vector bundle which is Nakano positive and for complex valued ...
Osama Abdelkader, Shaban Khidr
doaj  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Schouten Bracket of Holomorphic Tensors of a Kahlerian Manifold

Journal of Mathematical and Fundamental Sciences, 2019
. It is shown that the Schouten bracket of holomorphic tensors of a compact kahlerian manifold W defines a structure of graded complex Lie algebra on the space of holomorphic tensors of the manifold. We obtain an important proposition which generalizes a
Jorga Ibrahim
doaj  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source