Results 61 to 70 of about 6,762,809 (278)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

From Holonomy of the Ising Model Form Factors to n-Fold Integrals and the Theory of Elliptic Curves

Symmetry, Integrability and Geometry: Methods and Applications, 2007
We recall the form factors $f^(j)_{N,N}$ corresponding to the $lambda$-extension $C(N,N; lambda)$ of the two-point diagonal correlation function of the Ising model on the square lattice and their associated linear differential equations which exhibit ...
Salah Boukraa, Saoud Hassani, Jean-Marie Maillard, Nadjah Zenine   +3 more
doaj  

A public–private partnership to speed up potato breeding

Open Agriculture, 2020
The process to develop potato cultivars is complex and lengthy due to numerous reasons, viz., tetrasomic inheritance with heterozygous nature, large number of phenotypic recurrent selections, low efficiency of selections in early generations, slow ...
Sharma Neeraj, Sanders Wichard, Graveland Robert, Schoper John, Campos Hugo   +4 more
doaj   +1 more source

Tropical algebra for noise removal and optimal control

Journal of Low Frequency Noise, Vibration and Active Control, 2023
Algorithms for noise removal are either complex or ineffective, and the optimal control with inequality constrains makes the algorithm even more complex.
Chun-Mei Gong, Jiao Peng, Jing Wang
doaj   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Phenotypic and genetic analysis of udder health using SCC in Valle del Belice dairy sheep

Italian Journal of Animal Science, 2010
Intramammary infections (IMI) are a complex of inflammatory diseases which are defined as an inflammation of the mammary gland resulting from the introduction and multiplication of pathogenic micro-organisms.
P. Giaccone, A. Zumbo, M.T. Sardina, V. Riggio, B. Portolano   +4 more
doaj   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

A Rigorous Extension of the Schönhage-Strassen Integer Multiplication Algorithm Using Complex Interval Arithmetic [PDF]

Electronic Proceedings in Theoretical Computer Science, 2010
Multiplication of n-digit integers by long multiplication requires O(n^2) operations and can be time-consuming. In 1970 A. Schoenhage and V. Strassen published an algorithm capable of performing the task with only O(n log(n)) arithmetic operations over ...
Thomas Steinke, Raazesh Sainudiin
doaj   +1 more source

On Complex Numbers in Higher Dimensions

Axioms, 2022
The geometric approach to generalized complex and three-dimensional hyper-complex numbers and more general algebraic structures being based upon a general vector space structure and a geometric multiplication rule which was only recently developed is ...
Wolf-Dieter Richter
doaj   +1 more source