Results 81 to 90 of about 15,651,318 (279)

Planning an Healthcare Network: the case of Clinical Laboratories in Sicily

, 2014
Healthcare centers, private and public, are responsible for serving health demand of the population. Typically their respective geographical location and size is the result of a complex interaction between epidemiological, historical and economical ...
Sergio Pagano, Pierpaolo Cavallo
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Learning to build sustainable communities: an interdependency network perspective [PDF]

, 2013
This paper explores the production of sustainable communities from an interdependency network perspective (Newton, 2001). Drawing on fieldwork that examined how planners worked collaboratively with other professionals to address the challenges of ...
Lever, John, Smith, Ian, Ian Smith, John Lever   +3 more
core   +1 more source

The Evaluation of Node Importance in Urban Road Network Based on Complex Network Theory

MATEC Web of Conferences, 2016
Identifying and protecting traffic hub is vital to keep the stability and reliability of urban road traffic network. In this paper, a comprehensive evaluation method of node importance in urban road traffic network was introduced based on identification ...
Cao Hongmei, Liu Hao, Zhao Fang, Li Yuanyuan, Du Mingkun   +4 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Modeling of complex-valued Wiener systems using B-spline neural network

, 2011
In this brief, a new complex-valued B-spline neural network is introduced in order to model the complex-valued Wiener system using observational input/output data. The complex-valued nonlinear static function in the Wiener system is represented using the
Hong, Xia, null Sheng Chen, Chen, Sheng, null Xia Hong   +3 more
core   +2 more sources

A new approach for nuclear reactor analysis based on complex network theory

Progress in nuclear energy (New series), 2019
In this work, complex network theory is applied for the first time in the field of nuclear reactor physics to present a new approach for the evaluation of the multiplication factor of a nuclear system.
E. Cervi, A. Cammi, E. Zio
semanticscholar   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

A complex network approach to urban growth [PDF]

The economic geography can be viewed as a large and growing network of interacting activities. This fundamental network structure and the large size of such systems makes complex networks an attractive model for its analysis. In this paper we propose the
Alexander Hellervik, Claes Andersson, Koen Frenken   +2 more
core