Results 41 to 50 of about 4,739,253 (306)

Mucin-Protected Caco-2 Assay to Study Drug Permeation in the Presence of Complex Biorelevant Media

Pharmaceutics, 2022
The poor solubility and permeability of compounds beyond Lipinski’s Rule of Five (bRo5) are major challenges for cell-based permeability assays. Due to their incompatibility with gastrointestinal components in biorelevant media, the exploration of ...
Dong Ye, Álvaro López Mármol, Verena Lenz, Patricia Muschong, Anita Wilhelm-Alkubaisi, Manuel Weinheimer, Mirko Koziolek, Kerstin A. Sauer, Loic Laplanche, Mario Mezler   +9 more
doaj   +1 more source

One-dimensional fluid diffusion induced by constant-rate flow injection: Theoretical analysis and application to the determination of fluid permeability and specific storage of a cored rock sample [PDF]

, 2004
We describe the conceptual design and first application of a new method for simultaneously measuring the fluid permeability and specific storage of a rock sample.
Song, I., Odling, N. W., Smyth, N. F., Ngwenya, B. T., Elphick, S. C., Main, I. G.; id_orcid   +5 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Enhanced Electromagnetic Wave Absorption in W-Type Ba-Hexaferrites: Role of Composition and Grain Growth

Applied Sciences
W-type Ba-hexaferrite, BaZn2−xCoxFe16O27, was synthesized via both conventional solid-state (x = 0.4, 0.5, 0.6, 0.75, 1.0, 1.25, 1.5) and molten-salt methods (x = 0.75, 1.0, 1.25).
Jae-Hee Heo, Young-Min Kang
doaj   +1 more source

Mechanical, Magnetic, and Microstructural Characterization of Ni0.9Co0.1Fe2O4 Produced by the Ceramic Method [PDF]

Materials Research, 2018
Ni-Co ferrites, especially the ones with lower cobalt fractions, are candidate materials for applications in magnetomechanical sensors and electromagnetic wave absorbers.
Mônica Sumie Hieda, João Paulo Barros Machado, Eduardo de Oliveira Silva Júnior, Mateus Botani de Souza Dias, Cristina Bormio Nunes, Rodrigo Gabas Amaro de Lima, Antonio Carlos da Cunha Migliano, Vera Lúcia Othéro de Brito   +7 more
doaj   +1 more source

Cryptographic Puzzles and Complex Systems

, 2021
A puzzle lies behind password authentication (PA) and blockchain proof of work (PoW). A cryptographic hash function is commonly used to implement them. The potential problem with secure hash functions is their complexity and rigidity.
Vuckovac, Rade
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Preparation and characterization of standardized pomegranate extract-phospholipid complex as an effective drug delivery tool

Journal of Advanced Pharmaceutical Technology & Research, 2015
Punicalagins, a pair of anomeric ellagitannins, present in Punica granatum (Pomegranates) are known to possess excellent antioxidant activity in vitro, but poor oral bioavailability.
Amisha Kamlesh Vora, Vaishali Y Londhe, Nancy S Pandita   +2 more
doaj   +1 more source

The permeability transition pore complex in cancer cell death [PDF]

Oncogene, 2006
The permeability transition pore (PTP) is a multi-protein complex at contact sites of the inner with the outer mitochondrial membrane. Research over the past years has led to the concept that the PTP occupies a central role in cell death induction.
Brenner, Catherine, Grimm, S.
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source