Results 61 to 70 of about 4,739,253 (306)

Characterisation of the passive permeability barrier of nuclear pore complexes [PDF]

The EMBO Journal, 2009
Nuclear pore complexes (NPCs) restrict uncontrolled nucleocytoplasmic fluxes of inert macromolecules but permit facilitated translocation of nuclear transport receptors and their cargo complexes. We probed the passive barrier of NPCs and observed sieve-like properties with a dominating mesh or channel radius of 2.6 nm, which is narrower than proposed ...
Mohr, D., Frey, S., Fischer, T., Güttler, T., Görlich, D.   +4 more
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

RF measurement of wire complex permeability

Electronics Letters, 2003
The complex permeability of thin round wires is measured with a coaxial system at half-wavelength resonance, using surface impedance and low-loss transmission line concepts. A steel wire is measured over the band 300 MHz–3 GHz. The results compare well to measurements made early in the last century.
Stuart T.E.W., Reader H.C., Cloete J.H.
openaire   +2 more sources

Cell-permeable protein therapy for complex I dysfunction [PDF]

Journal of Bioenergetics and Biomembranes, 2014
Complex I deficiency is difficult to treat because of the size and complexity of the multi-subunit enzyme complex. Mutations or deletions in the mitochondrial genome are not amenable to gene therapy. However, animal studies have shown that yeast-derived internal NADH quinone oxidoreductase (Ndi1) can be delivered as a cell-permeable recombinant protein
Salvatore, Pepe, Robert M, Mentzer, Roberta A, Gottlieb   +2 more
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Study of structural, dielectric, and magnetic properties of nickel doped strontium hexaferrite nanoparticles for microwave absorption application

Materials Research Express
This study presents the fabrication of nickel-doped strontium hexaferrite nanoparticles via the sol–gel auto-combustion technique to evaluate their potential as efficient microwave absorbing materials. A compositional series of Sr _1−x Ni _x Fe _12 O _19
Abdul Karim, Iftikhar Hussain Gul
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

A new permeability calculation method using nuclear magnetic resonance logging based on pore sizes: A case study of bioclastic limestone reservoirs in the A oilfield of the Mid-East

Petroleum Exploration and Development, 2018
It is difficult to accurately obtain the permeability of complex lithologic reservoirs using conventional methods because they have diverse pore structures and complex seepage mechanisms.
Yujiao HAN, Cancan ZHOU, Yiren FAN, Chaoliu LI, Chao YUAN, Yunhai CONG   +5 more
doaj   +1 more source

Complex permeability of polycrystalline Mn-Zn and Ni-Zn ferrites

Electrical Engineering in Japan, 1997
The complex permeability of ferrites is frequency dependent. The real part of the complex permeability deteriorates in a high frequency range and the imaginary part has a peak after starting the deterioration. This paper examines the possibility that the frequency characteristics for some ferrites can be approximately derived from a first-order linear ...
Hideo Saotome, Yo Sakaki
openaire   +2 more sources