Results 41 to 50 of about 85,609 (247)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Journal of Materials Research and TechnologyThe hydrogen embrittlement (HE) of sheared edges is a concern in advanced high-strength steel owing to their localized susceptibility to HE. This study investigated the HE of sheared edges from a microstructural perspective.
Jisung Yoo +8 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Journal of Materials Research and TechnologyHigh strength steels are susceptible to hydrogen embrittlement that may contribute to degradation of steel parts and structural failure. The correlation between corrosion-induced hydrogen entry and electrochemical behavior of galvanized advanced high ...
Maryna Taryba +5 more
doaj +1 more source
Effect of Y2Ti2O7 nanoparticles on inclusions in CLAM steel
工程科学学报, 2020 As the preferred material for the first wall of fusion reactors, China’s low-activation martensitic (CLAM) steel has several advantages; however, its high-temperature (>550 ℃) strength is not enough, and the helium produced by fusion can easily form a ...
Jia-xi WANG +5 more
doaj +1 more source
Zaštita Materijala, 2022 The corrosion resistance of mild steel in simulated concrete pore solution (SCPS) in the absence and presence of thiourea has been investigated by polarization study and AC impedance spectra.
Krishnasamy Vigneswari +8 more
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Metals, 2021 With its excellent property combinations and ability to specifically adjust tailor-made microstructures, steel is still the world’s most important engineering and construction material. To fulfill ever-increasing demands and tighter tolerances in today’s
Martin Müller +3 more
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source