Results 131 to 140 of about 4,310,904 (314)

Potential uses of Bayesian networks as tools for synthesis of systematic reviews of complex interventions

, 2014
Bayesian networks (BNs) are tools for representing expert knowledge or evidence. They are especially useful for synthesising evidence or belief concerning a complex intervention, assessing the sensitivity of outcomes to different situations or contextual
Meader, N., Mengersen, K., Stewart, G.B.
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Potential games in volatile environments [PDF]

This papers studies the co-evolution of networks and play in the context of finite population potential games. Action revision, link creation and link destruction are combined in a continuous-time Markov process.
Mathias Staudigl
core  

The value of mixed methods for researching complex interventions

, 2015
In the twenty-first century, it is more obvious than ever before that health services research and its practitioners exist in an extremely complex contextual environment.
Borglin, Gunilla,
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Human pilot studies reveal the potential of a vitronectin: Growth factor complex as a treatment for chronic wounds

, 2011
Several different advanced treatments have been used to improve healing in chronic wounds, but none have shown sustained success. The application of topical growth factors (GFs) has displayed some potential, but the varying results, high doses and high ...
Van Lonkhuyzen, Derek, Fleming, Jacqui-Lee, Leavesley, David I., Wallace, Hilary J., Queen, Douglas, Rayment, Erin A., Erin A Rayment, David I Leavesley, Sibbald, Gary, Sibbald, R. Gary, Gary K Shooter, Michael C Stacey, Wallace, Hilary, Broszczak, Daniel, Sim Yeoh-Ellerton, Leavesley, David, Shooter, Gary, Douglas Queen, Yeoh-Ellerton, Sim, Zee Upton, Jacqui M Fleming, Daniel Broszczak, Derek R van Lonkhuyzen, Upton, Zee, Stacey, Michael C., Hilary J Wallace, van Lonkhuyzen, Derek R., Fleming, Jacqui M., Stacey, Michael, Rayment, Erin, R Gary Sibbald, Shooter, Gary K.   +31 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

The Na(+)-H(2) cation complex: Rotationally resolved infrared spectrum, potential energy surface, and rovibrational calculations

, 2008
The rotationally resolved infrared spectrum of the Na(+)-H(2) cation complex is recorded in the H-H stretch region (4067-4118 cm(-1)) by monitoring the production of Na(+) photofragments.
J. Kłos, Bieske, E. J., Alexander, M. H., D. I. G. Bennett, B. L. J. Poad, Bennett, D. I. G., E. J. Bieske, M. H. Alexander, Klos, J., P. J. Wearne, Buchachenko, A. A., Poad, B. L. J., A. A. Buchachenko, Wearne, P. J.   +13 more
core   +1 more source